TNF-α and adipocyte biology

被引：502

作者：

Cawthorn, William P. ^{[1
]}

Sethi, Jaswinder K. ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 0QQ, England

来源：

FEBS LETTERS | 2008年 / 582卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

obesity; type; 2; diabetes; metabolic syndrome; insulin resistance; dyslipidemia; TNF signalling; lipid metabolism; antiadipogenesis;

D O I：

10.1016/j.febslet.2007.11.051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dyslipidemia and insulin resistance are commonly associated with catabolic or lipodystrophic conditions (such as cancer and sepsis) and with pathological states of nutritional overload (such as obesity-related type 2 diabetes). Two common features of these metabolic disorders are adipose tissue dysfunction and elevated levels of tumour necrosis factor-alpha (TNF-alpha). Herein, we review the multiple actions of this pro-inflammatory adipokine on adipose tissue biology. These include inhibition of carbohydrate metabolism, lipogenesis, adipogenesis and thermogenesis and stimulation of lipolysis. TNF-alpha can also impact the endocrine functions of adipose tissue. Taken together, TNF-alpha contributes to metabolic dysregulation by impairing both adipose tissue function and its ability to store excess fuel. The molecular mechanisms that underlie these actions are discussed. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：117 / 131

页数：15

共 184 条

[41] Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases
Gao, ZG
Zuberi, A
Quon, MJ
Dong, ZG
Ye, JP
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (27) : 24944 - 24950
[42] Serine phosphorylation of insulin receptor substrate 1 by inhibitor κB kinase complex
Gao, ZG
Hwang, D
Bataille, F
Lefevre, M
York, D
Quon, M
Ye, JP
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (50) : 48115 - 48121
[43] PURIFICATION AND CHARACTERIZATION OF AN INHIBITOR (SOLUBLE TUMOR-NECROSIS-FACTOR RECEPTOR) FOR TUMOR-NECROSIS-FACTOR AND LYMPHOTOXIN OBTAINED FROM THE SERUM ULTRAFILTRATES OF HUMAN CANCER-PATIENTS
GATANAGA, T
HWANG, CD
KOHR, W
CAPPUCCINI, F
LUCCI, JA
JEFFES, EWB
LENTZ, R
TOMICH, J
YAMAMOTO, RS
GRANGER, GA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (22) : 8781 - 8784
[44] NF-κB activation by reactive oxygen species:: Fifteen years later
Gloire, Geoffrey
Legrand-Poels, Sylvie
Piette, Jacques
[J]. BIOCHEMICAL PHARMACOLOGY, 2006, 72 (11) : 1493 - 1505
[45] Good Manuela, 2006, Diab Vasc Dis Res, V3, P26, DOI 10.3132/dvdr.2006.003
[46] Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
Grant, SFA
Thorleifsson, G
Reynisdottir, I
Benediktsson, R
Manolescu, A
Sainz, J
Helgason, A
Stefansson, H
Emilsson, V
Helgadottir, A
Styrkarsdottir, U
Magnusson, KP
Walters, GB
Palsdottir, E
Jonsdottir, T
Gudmundsdottir, T
Gylfason, A
Saemundsdottir, J
Wilensky, RL
Reilly, MP
Rader, DJ
Bagger, Y
Christiansen, C
Gudnason, V
Sigurdsson, G
Thorsteinsdottir, U
Gulcher, JR
Kong, A
Stefansson, K
[J]. NATURE GENETICS, 2006, 38 (03) : 320 - 323
[47] Stimulation of lipolysis by tumor necrosis factor-α in 3T3-L1 Adipocytes is glucose dependent -: Implications for long-term regulation of lipolysis
Green, A
Rumberger, JM
Stuart, CA
Ruhoff, MS
[J]. DIABETES, 2004, 53 (01) : 74 - 81
[48] TUMOR-NECROSIS-FACTOR INCREASES THE RATE OF LIPOLYSIS IN PRIMARY CULTURES OF ADIPOCYTES WITHOUT ALTERING LEVELS OF HORMONE-SENSITIVE LIPASE
GREEN, A
DOBIAS, SB
WALTERS, DJA
BRASIER, AR
[J]. ENDOCRINOLOGY, 1994, 134 (06) : 2581 - 2588
[49] Grell M, 1996, J INFLAMM, V47, P8
[50] Inhibition of ceramide production reverses TNF-induced insulin resistance
Grigsby, RJ
Dobrowsky, RT
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 287 (05) : 1121 - 1124

← 1 2 3 4 5 6 7 8 9 10 →