The Cbl interactome and its functions

被引：328

作者：

Schmidt, MHH

Dikic, I ^{[1
]}

机构：

[1] Mediterranean Inst Life Sci, MedILS, Mazuranicevo Setaliste BB, HR-21000 Split, Croatia

[2] Goethe Univ Frankfurt, Inst Biochem 2, D-60590 Frankfurt, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 12期

关键词：

D O I：

10.1038/nrm1762

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cbl proteins are ubiquitin ligases and multifunctional adaptor proteins that are implicated in the regulation of signal transduction in various cell types and in response to different stimuli. Cbl-associated proteins can assemble together at a given time or space inside the cell, and such an interactome can form signal competent networks that control many physiological processes. Dysregulation of spatial or temporal constraints in the Cbl interactome results in the development of human pathologies such as immune diseases, diabetes and cancer.

引用

收藏

页码：907 / 918

页数：12

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