Efficient synthesis of enantiopure β-amino-γ-keto acids from L-homoserine

被引：10

作者：

Sharma, AK ^{[1
]}

Hergenrother, PJ ^{[1
]}

机构：

[1] Univ Illinois, Roger Adams Lab, Dept Chem, Urbana, IL 61801 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 12期

关键词：

D O I：

10.1021/ol0345327

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A variety of beta-amino-gamma-keto acids were prepared in four steps from commercially available L-homoserine. The reaction sequence is highlighted by a Ni-catalyzed Grignard addition to a N-protected derivative Of L-homoserine. One of the beta-amino-gamma-keto acids was then used to create a beta-peptide trimer composed solely of beta-amino-gamma-keto acids.

引用

页码：2107 / 2109

页数：3

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