Liquid chromatographic electrospray mass spectrometric study of the phthalides of Angelica sinensis and chemical changes of Z-ligustilide

被引：114

作者：

Lin, LZ ^{[1
]}

He, XG ^{[1
]}

Lian, LZ ^{[1
]}

King, W ^{[1
]}

Elliot, J ^{[1
]}

机构：

[1] E Earth Herb Inc, Res Lab Nat Prod Chem, Eugene, OR 97402 USA

来源：

JOURNAL OF CHROMATOGRAPHY A | 1998年 / 810卷 / 1-2期

关键词：

Angelica sinenesis; Danggui; ligustilide; phthalides; coniferyl ferulate;

D O I：

10.1016/S0021-9673(98)00201-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

High-performance liquid chromatography-electrospray ionization-mass spectrometry has been applied to analyze the chemical constituents of Danggui (the rhizome of Angelica sinensis) and to study chemical changes of Z-ligustilide. Twelve phthalides were unambiguously identified as senkyunolide I (3), senkyunolide H (4), sedanenolide (8), butylphthalide (9), E-ligustilide (13), Z-ligustilide (14), Z-butylidenephthalide (15), Z,Z'-6.8',7.3' -diligustilide (16), angelicide (17), levistolide A (18), Z-ligustilide dimer E-232 (19) and Z,Z'-3.3',8.8'-diligustilide (20) in Danggui extract. The existence of 12 other phthalides (2, 5-7, 11, 12, 22-27), ferulic acid (1) and coniferyl ferulate (10) in Danggui extract has also been demonstrated. Phthalides 3, 4, 16-18 and 20 were determined to be the products from chemical change of Z-ligustilide. This is the first report of the existence of 16 compounds (2-8, 10-12, 20, 22-25 and 27) in Danggui extract. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：71 / 79

页数：9