Mechanisms of Disease: new therapeutic strategies for Alzheimer's disease - targeting APP processing in lipid rafts

被引：81

作者：

Cheng, Haipeng ^{[1
]}

Vetrivel, Kulandaivelu S. ^{[1
]}

Gong, Ping ^{[1
]}

Meckler, Xavier ^{[1
]}

Parent, Angele ^{[1
]}

Thinakaran, Gopal ^{[1
]}

机构：

[1] Univ Chicago, Dept Neurobiol, Chicago, IL 60637 USA

来源：

NATURE CLINICAL PRACTICE NEUROLOGY | 2007年 / 3卷 / 07期

关键词：

Alzheimer's disease; amyloid; amyloid precursor protein; cholesterol; li; pid rafts;

D O I：

10.1038/ncpneuro0549

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease (AD) is the most common cause of age- related dementia. Pathologically, AD is characterized by the deposition in the brain of amyloid-beta peptides derived from proteolysis of amyloid precursor protein (APP) by beta-site APP cleaving enzyme 1 (BACE1) and gamma-secretase. A growing body of evidence implicates cholesterol and cholesterol- rich membrane microdomains in amyloidogenic processing of APP. Here, we review recent findings regarding the association of BACE1, gamma-secretase and APP in lipid rafts, and discuss potential therapeutic strategies for AD that are based on knowledge gleaned from the membrane environment that fosters APP processing.

引用

收藏

页码：374 / 382

页数：9

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