Asymmetric Diels Alder reaction using pyrazole derivatives as a chiral catalyst

被引：25

作者：

Kashima, C ^{[1
]}

Miwa, Y ^{[1
]}

Shibata, S ^{[1
]}

Nakazono, H ^{[1
]}

机构：

[1] Univ Tsukuba, Dept Chem, Tsukuba, Ibaraki 3058571, Japan

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2003年 / 40卷 / 04期

关键词：

D O I：

10.1002/jhet.5570400420

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Acylpyrazoles (1) were promising as good dienophiles, which were easily converted into the desired carboxylic derivatives. Bis(pyrazolyl)methanes, which were derived from chiral pyrazoles, showed the activity of chiral catalyst. Particularly 10 mol% of bis(isomenthopyrazol-1,1'-yl)methane (8a) catalyzed enantioselectively the Diels Alder reaction up to 40 % ee by the formation of complex with Mg(ClO4)(2).

引用

页码：681 / 688

页数：8

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