Monoamine oxidase inhibitors from rhizoma of Coptis chinensis

被引：94

作者：

Kong, LD

Cheng, CHK

Tan, RX ^{[1
]}

机构：

[1] Nanjing Univ, Sch Life Sci, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

[2] Chinese Univ Hong Kong, Dept Biochem, Shatin, Hong Kong, Peoples R China

[3] Lanzhou Univ, Natl Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

PLANTA MEDICA | 2001年 / 67卷 / 01期

关键词：

D O I：

10.1055/s-2001-10874

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three protoberberine alkaloids jatrorrhizine, berberine and palmatine were isolated from the monoamine oxidase (MAO) inhibitory fraction of the methanol extract of Coptis chinensis rhizoma. Jatrorrhizine was shown to inhibit non-competitively both MAO-A and -B from rat brain mitochondria with the IC50 values of 4 and 62 muM, respectively. Berberine only competitively inhibited MAO-A with an IC50 values of 126 muM whereas palmatine exhibited, up to 200 muM, no inhibition on any type of the enzyme. The structure-activity relationship was briefly discussed.

引用

页码：74 / 76

页数：3

共 20 条

[1] AN UPDATE OF RECENT MOCLOBEMIDE INTERACTION DATA [J].

DINGEMANSE, J .

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 1993, 7 (3-4) :167-180

[2]

FANG XP, 1989, CHUNG KUO CHUNG YAO, V14, P33

[3]

FANG XP, 1989, CHINA J CHINESE MAT, V14, P63

[4] INTERACTION BETWEEN HUMAN-PLATELET MONO-AMINE OXIDASE, ITS MONO-AMINE SUBSTRATES AND OXYGEN [J].

FOWLER, CJ ;

EKSTEDT, B ;

EGASHIRA, T ;

KINEMUCHI, H ;

ORELAND, L .

BIOCHEMICAL PHARMACOLOGY, 1979, 28 (20) :3063-3068

[5] EFFECTS OF PALMATINE ON MOTOR-ACTIVITY AND THE CONCENTRATION OF CENTRAL MONOAMINES AND ITS METABOLITES IN RATS [J].

HSIEH, MT ;

SU, SH ;

TSAI, HY ;

PENG, WH ;

HSIEH, CC ;

CHEN, CF .

JAPANESE JOURNAL OF PHARMACOLOGY, 1993, 61 (01) :1-5

[6] Antimicrobial activity of some 13-alkyl substituted protoberberinium salts [J].

Iwasa, K ;

Kamigauchi, M ;

Sugiura, M ;

Nanba, H .

PLANTA MEDICA, 1997, 63 (03) :196-198

[7]

*JIANGS COLL NEW M, 1986, DICT TRAD CHIN MED, P2022

[8] SHORT REVIEW ON MONOAMINE-OXIDASE AND ITS INHIBITORS [J].

KANAZAWA, I .

EUROPEAN NEUROLOGY, 1994, 34 :36-39

[9] Cytotoxicity of 1-amino-4-phenyl-1,2,3,6-tetrahydropyridine and 1-amino-4-phenylpyridinium ion, 1-amino analogues of MPTP and MPP+, to clonal pheochromocytoma PC12 cells [J].

Kohda, K ;

Noda, Y ;

Aoyama, S ;

Umeda, M ;

Sumino, T ;

Kaiya, T ;

Maruyama, W ;

Naoi, M .

CHEMICAL RESEARCH IN TOXICOLOGY, 1998, 11 (11) :1249-1253

[10]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

← 1 2 →