The role of local drug delivery in the management of periodontal diseases: A comprehensive review

被引:169
作者
Greenstein, G
Polson, A
机构
[1] Univ Med & Dent New Jersey, Dept Periodontol, Newark, NJ 07103 USA
[2] Univ Penn, Sch Dent Med, Dept Periodontol, Philadelphia, PA 19104 USA
关键词
comparative study; drug delivery systems; periodontal diseases drug therapy;
D O I
10.1902/jop.1998.69.5.507
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
THIS REVIEW ARTICLE EVALUATES the role of local drug delivery systems in the management of periodontal diseases. The efficacy of several local delivery devices (i.e., tetracycline fibers, metronidazole and minocycline gels, chlorhexidine chips, and doxycycline polymer) which are either commercially available in the United States or abroad, or are currently under consideration for Food and Drug Administration (FDA) approval are discussed. The drug delivery systems are assessed with regard to their functional characteristics, effectiveness as a monotherapy, as compared to scaling and root planing, and ability to enhance conventional therapy. Furthermore, controversies associated with local delivery are addressed (e.g., induction of bacterial resistant strains, the efficacy of systemic versus local drug delivery, and whether local drug delivery should function as an alternative or as an adjunct to conventional treatment).
引用
收藏
页码:507 / 520
页数:14
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