The natriuretic peptide (OVCNP-39) from platypus (Ornithorhynchus anatinus) venom relaxes the isolated rat uterus and promotes oedema and mast cell histamine release

被引：36

作者：

De Plater, GM

Martin, RL ^{[1
]}

Milburn, PJ

机构：

[1] Australian Natl Univ, Div Bot & Zool, Canberra, ACT 0200, Australia

[2] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia

来源：

TOXICON | 1998年 / 36卷 / 06期

基金：

澳大利亚研究理事会;

关键词：

D O I：

10.1016/S0041-0101(97)00176-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study we characterise the ability of a C-type natriuretic peptide from platypus (Ornithorhynchus anatinus) venom (ovCNP-39) to relax the rat uterus in vitro and we investigate the possibility that ovCNP-39 contributes to the acute effects of envenomation, which include oedema, pain and erythema. We have found that both ovCNP-39 and the endogenous C-type natriuretic peptide, CNP-22, produce oedema in the rat paw and release histamine from rat peritoneal mast cells. Two synthetic peptides, ovCNP-39(1-17) and ovCNP-39(18-39), corresponding to the N- and C-termini, respectively, are equipotent histamine releasers, suggesting that ovCNP-39 and other natriuretic peptides do not act through conventional natriuretic peptide receptors on mast cells. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：847 / 857

页数：11

共 33 条

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