Synthesis of S-linked glycosyl amino acids in aqueous solution with unprotected carbohydrates

被引：46

作者：

Cohen, SB ^{[1
]}

Halcomb, RL ^{[1
]}

机构：

[1] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 03期

关键词：

D O I：

10.1021/ol006908b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The cyclic sulfamidate 5 was synthesized in 60% overall yield from L-serine benzyl ester, Compound 5 reacted cleanly with the sodium thiolate salt of a variety of unprotected 1-thio sugars in aqueous buffer to afford the corresponding S-linked amino acid glycoconjugates in good yields after hydrolysis of the N-sulfates.

引用

页码：405 / 407

页数：3

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← 1 2 3 →