Neuroinflammatory processes in Parkinson's disease

被引：164

作者：

Hirsch, EC ^{[1
]}

Hunot, S ^{[1
]}

Hartmann, A ^{[1
]}

机构：

[1] Hop La Pitie Salpetriere, INSERM, U675, F-75651 Paris, France

来源：

PARKINSONISM & RELATED DISORDERS | 2005年 / 11卷

关键词：

glial cells; cytokines; dopamine neurons; apoptosis; neuroprotection;

D O I：

10.1016/j.parkreldis.2004.10.013

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In Parkinson's disease (PD), post-mortem examination reveals a loss of dopaminergic (DA) neurons in the substantia nigra (SN) associated with a massive astrogliosis and the presence of activated microglial cells. Similarly, microglial activation has also been reported to be associated with the loss of DA neurons in animal models of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), rotenone, annonacine and lipopolysaccharide (LPS). Recent evidence suggests that the disease may progress even when the initial cause of neuronal degeneration has disappeared, raising the possibility that toxic substances released by glial cells could be involved in the propagation of neuronal degeneration. Inhibition of the glial reaction and the inflammatory processes may thus represent a therapeutic target to reduce neuronal degeneration in PD. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：S9 / S15

页数：7

共 80 条

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