TRAIL: a molecule with multiple receptors and control mechanisms

被引：421

作者：

Griffith, TS ^{[1
]}

Lynch, DH ^{[1
]}

机构：

[1] Immunex Res & Dev Corp, Dept Immunol, Seattle, WA 98101 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(98)80224-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Apoptosis research is benefiting from bioinformatic approaches to identify new components of the cell death machinery and novel cell death inducers/receptors. Over the past year, knowledge of the system involving TNF-related apoptosis-inducing ligand (TRAIL) and its receptors has increased via genomic database analysis to include four distinct receptors that interact with a single ligand. Currently, these molecules are of major interest due to their potential roles and application in cancer therapy.

引用

页码：559 / 563

页数：5

共 25 条

[1] CRYSTAL-STRUCTURE OF THE SOLUBLE HUMAN 55 KD TNF RECEPTOR-HUMAN TNF-BETA COMPLEX - IMPLICATIONS FOR TNF RECEPTOR ACTIVATION [J].

BANNER, DW ;

DARCY, A ;

JANES, W ;

GENTZ, R ;

SCHOENFELD, HJ ;

BROGER, C ;

LOETSCHER, H ;

LESSLAUER, W .

CELL, 1993, 73 (03) :431-445

[2] An essential role for NF-kappa B in preventing TNF-alpha-induced cell death [J].

Beg, AA ;

Baltimore, D .

SCIENCE, 1996, 274 (5288) :782-784

[3] Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-κB pathway [J].

Chaudhary, PM ;

Eby, M ;

Jasmin, A ;

Bookwalter, A ;

Murray, J ;

Hood, L .

IMMUNITY, 1997, 7 (06) :821-830

[4]

Chinnaiyan AM, 1996, CURR BIOL, V6, P555

[5] The novel receptor TRAIL-R4 induces NF-κB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain [J].

Degli-Esposti, MA ;

Dougall, WC ;

Smolak, PJ ;

Waugh, JY ;

Smith, CA ;

Goodwin, RG .

IMMUNITY, 1997, 7 (06) :813-820

[6] Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family [J].

DegliEsposti, MA ;

Smolak, PJ ;

Walczak, H ;

Waugh, J ;

Huang, CP ;

DuBose, RF ;

Goodwin, RG ;

Smith, CA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (07) :1165-1170

[7] GENETIC-CONTROL OF PROGRAMMED CELL-DEATH IN THE NEMATODE C-ELEGANS [J].

ELLIS, HM ;

HORVITZ, HR .

CELL, 1986, 44 (06) :817-829

[8] In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains [J].

FernandesAlnemri, T ;

Armstrong, RC ;

Krebs, J ;

Srinivasula, SM ;

Wang, L ;

Bullrich, F ;

Fritz, LC ;

Trapani, JA ;

Tomaselli, KJ ;

Litwack, G ;

Alnemri, ES .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) :7464-7469

[9]

GRIFFITH TS, 1998, IN PRESS J IMMUNOL, V161

[10] THE GENETICS OF PROGRAMMED CELL-DEATH IN THE NEMATODE CAENORHABDITIS-ELEGANS [J].

HORVITZ, HR ;

SHAHAM, S ;

HENGARTNER, MO .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1994, 59 :377-385

← 1 2 3 →