TRAIL: a molecule with multiple receptors and control mechanisms

被引：422

作者：

Griffith, TS ^{[1
]}

Lynch, DH ^{[1
]}

机构：

[1] Immunex Res & Dev Corp, Dept Immunol, Seattle, WA 98101 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(98)80224-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Apoptosis research is benefiting from bioinformatic approaches to identify new components of the cell death machinery and novel cell death inducers/receptors. Over the past year, knowledge of the system involving TNF-related apoptosis-inducing ligand (TRAIL) and its receptors has increased via genomic database analysis to include four distinct receptors that interact with a single ligand. Currently, these molecules are of major interest due to their potential roles and application in cancer therapy.

引用

页码：559 / 563

页数：5

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