Omeprazole inhibits natural killer cell functions

被引：26

作者：

Alkim, Huseyin ^{[1
,2
]}

Unal, Selahattin ^{[2
]}

Okur, Hamza ^{[3
]}

Imir, Turgut ^{[3
]}

机构：

[1] Unsal Karahan Sistesi, Ihlamur Yolu Cikmazi, Nisantas Ihlamir Yolu, TR-34365 Istanbul, Turkey

[2] Gazi Univ, Fac Med, Dept Gastroenterol, Ankara, Turkey

[3] Gazi Univ, Fac Med, Dept Immunol, Ankara, Turkey

来源：

DIGESTIVE DISEASES AND SCIENCES | 2008年 / 53卷 / 02期

关键词：

omeprazole; natural killer cells; conjugation; cytotoxicity; H+-K+ ATPase;

D O I：

10.1007/s10620-007-9869-2

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This study was designed to determine the possible effects of omeprazole on human natural killer cells. Peripheral venous blood samples were taken from 20 peptic ulcer patients before and at the 14th and the 28th days of omeprazole treatment. Mononuclear cells were removed from blood and their capability of making conjugation with K562 target cells and lysing K562 target cells was evaluated. A significant decrease was found (P < 0.001) in the 14th and the 28th days compared with the basal value of the capability of the mononuclear cells to conjugate with the K562 target cells and to lyse them. This study demonstrated that omeprazole significantly reduces natural killer cell functions. This finding suggests that omeprazole may also have some effects on the other systems in addition to parietal cell acid secretion.

引用

页码：347 / 351

页数：5

共 28 条

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