1,2,4-triazolo mercapto and aminonitriles as potent antifungal agents

被引：145

作者：

Collin, X

Sauleau, A

Coulon, J

机构：

[1] Fac Pharm, Dept Pharmaceut Chem, F-35043 Rennes, France

[2] UHP Nancy 1, CNRS, Dept Microbial Chem, Fac Pharm,LCPME,UMR 7564, F-54001 Nancy, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(03)00378-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 3-mercapto-1,2,4-triazoles mono or disubstituted at 2-, 3- or 4-positions were synthesized and evaluated as antifungal agents. Many of these derivatives exhibit high activity against Candida albicans and Candida tropicalis. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：2601 / 2605

页数：5

相关论文

共 12 条

[1] Antifungal resistance trends towards the year 2000 - Implications for therapy and new approaches [J].

Alexander, BD ;

Perfect, JR .

DRUGS, 1997, 54 (05) :657-678

[2] Synthesis of 25-aminosterols, new antifungal agents [J].

Beuchet, P ;

Dherbomez, M ;

Elkiel, L ;

Charles, G ;

Letourneux, Y .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (11) :1599-1600

[3] Synthesis and antimicrobial activities of some 3-arylamino-5-[2(substituted 1-imidazolyl)ethyl]-1,2,4-triazole derivatives [J].

Demirayak, S ;

Benkli, K ;

Güven, K .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2000, 35 (11) :1037-1040

[4]

GHANNOUM MA, 1983, MICROBIOS, V37, P151

[5] 4-AMINO-3-MERCAPTO-4H-1,2,4-TRIAZOLES AND PROPARGYL ALDEHYDES - A NEW ROUTE TO 3-R-8-ARYL-1,2,4-TRIAZOLO[3,4-B]-1,3,4-THIADIAZEPINES [J].

HEINDEL, ND ;

REID, JR .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1980, 17 (05) :1087-1088

[6] SYNTHESIS, STRUCTURAL CHARACTERIZATION, CRYSTALLOGRAPHIC ANALYSIS AND ANTIBACTERIAL PROPERTIES OF SOME NITROFURYL TRIAZOLO[3,4-B]-1,3,4-THIADIAZINES [J].

HOLLA, BS ;

KALLURAYA, B ;

SRIDHAR, KR ;

DRAKE, E ;

THOMAS, LM ;

BHANDARY, KK ;

LEVINE, MJ .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1994, 29 (04) :301-308

[7] Treatment of fungal infection in AIDS [J].

Hood, S ;

Denning, DW .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1996, 37 :71-85

[8] The use of fluconazole and itraconazole in the treatment of Candida albicans infections:: a review [J].

Martin, MV .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1999, 44 (04) :429-437

[9] FUSARIUM INFECTIONS IN IMMUNOCOMPROMISED PATIENTS - CASE-REPORTS AND LITERATURE-REVIEW [J].

RABODONIRINA, M ;

PIENS, MA ;

MONIER, MF ;

GUEHO, E ;

FIERE, D ;

MOJON, M .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1994, 13 (02) :152-161

[10] IMPROVED SYNTHESES OF 5-SUBSTITUTED-4-AMINO-3-MERCAPTO-(4H)-1,2,4-TRIAZOLES [J].

REID, JR ;

HEINDEL, ND .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1976, 13 (04) :925-926