Synthesis of 25-aminosterols, new antifungal agents

被引：17

作者：

Beuchet, P ^{[1
]}

Dherbomez, M ^{[1
]}

Elkiel, L ^{[1
]}

Charles, G ^{[1
]}

Letourneux, Y ^{[1
]}

机构：

[1] Univ Rochelle, Lab Synth & Etude Subst Nat Activites Biol, F-17042 La Rochelle 01, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(99)00233-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

25-aminolanostenol 1 and 25-aminocholesterol 2 were hemisynthesized from natural sterols and tested in vitro against Candida albicans. The biological activity of compound 1 was rather weak, whereas 2 exhibited in vitro antifungal activity With MIC value of 4 mu M. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1599 / 1600

页数：2

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