Synthesis of 6(α,β)-aminocholestanols as ergosterol biosynthesis inhibitors

被引：17

作者：

Beuchet, P ^{[1
]}

El kihel, L ^{[1
]}

Dherbomez, M ^{[1
]}

Charles, G ^{[1
]}

Letourneux, Y ^{[1
]}

机构：

[1] Univ La Rochelle, Lab Synth & Etud Subst Nat Act Biol, F-17042 La Rochelle 01, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(98)00661-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Delta(7)-5-Desaturase catalyses one of the last steps in ergosterol biosynthesis in fungi. Moreover Delta 5-unsaturation is necessary for the sparking function. Synthesis of three pairs of C-6 epimeric cholestanol derivatives are described as potential growth inhibitors. Preliminary results suggest that 6 beta-aminocholestanol is a potent antifungal agent. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3627 / 3630

页数：4

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