First total synthesis of the mastigophorenes C and D and of simplified unnatural analogs

被引：19

作者：

Bringmann, G ^{[1
]}

Pabst, T ^{[1
]}

Henschel, P ^{[1
]}

Michel, M ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

来源：

TETRAHEDRON | 2001年 / 57卷 / 07期

关键词：

mastigophorene C; mastigophorene D; natural products; sesquiterpenes;

D O I：

10.1016/S0040-4020(00)01131-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of the mastigophorenes C (2) and D (3), natural 'dimeric' sesquiterpenes isolated from the livenwort Mastigophora diclados with interesting biological activities, is described. As previously for mastigophorenes A (1) and B, the divergent synthetic approach was first optimized on a simplified model system with a tert-butyl group instead of the chiral cyclopentyl residue, also in order to find more easily available compounds with similar or even improved biological activity. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1269 / 1275

页数：7

共 15 条

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