Novel concepts in directed biaryl synthesis, part 89 - From dynamic to non-dynamic kinetic resolution of lactone-bridged biaryls: Synthesis of mastigophorene B
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作者:
Bringmann, G
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机构:Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany
Bringmann, G
Hinrichs, J
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机构:Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany
Hinrichs, J
Pabst, T
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机构:Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany
Pabst, T
Henschel, P
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机构:Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany
Henschel, P
Peters, K
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机构:Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany
Peters, K
Peters, EM
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机构:Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany
Peters, EM
机构:
[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany
[2] Max Planck Inst Festkorperforsch, D-70506 Stuttgart, Germany
The atroposelective ring cleavage of configurationally unstable biaryl lactones, by dynamic kinetic resolution, is an efficient tool for the stereoselective synthesis of axially chiral biaryl target molecules. The recent extension of this methodology to the kinetic resolution of configurationally stable biaryl lactones and its application to natural product synthesis is described herein, exemplarily for the preparation of the nerve-growth stimulating dimeric sesquiterpene mastigophorene B.