Studies on novel synthetic methodologies, part 59.: A simple and efficient method for α-bromination of carbonyl compounds using N-bromosuccinimide in the presence of silica-supported sodium hydrogen sulfate as a heterogeneous catalyst

被引：102

作者：

Das, B ^{[1
]}

Venkateswarlu, K ^{[1
]}

Mahender, G ^{[1
]}

Mahender, L ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem 1, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 17期

关键词：

carbonyl compounds; alpha-bromination; NBS; NaHSO4 center dot SiO2; heterogeneous catalyst;

D O I：

10.1016/j.tetlet.2005.03.020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Bromination of carbonyl compounds (cyclic and acyclic ketones, amides and beta-ketoesters) has been achieved efficiently by treatment with N-bromosuccinimide (NBS) and catalyzed by silica-supported sodium hydrogen sulfate (NaHSO(4)center dot SiO2). The products were formed in high yields under mild reaction conditions and in short reaction times. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3041 / 3044

页数：4

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