Modified vaccinia virus Ankara protects macaques against respiratory challenge with monkeypox virus

被引：171

作者：

Stittelaar, KJ

van Amerongen, G

Kondova, I

Kuiken, T

van Lavieren, RF

Pistoor, FHM

Niesters, HGM

van Doornum, G

van der Zeijst, BAM

Mateo, L

Chaplin, PJ

Osterhaus, ADME

机构：

[1] Erasmus Univ, Med Ctr, Dept Virol, NL-3000 DR Rotterdam, Netherlands

[2] Netherlands Vaccine Inst, NL-3720 AL Bilthoven, Netherlands

[3] Biomed Primate Res Ctr, Dept Anim Sci, NL-2280 GH Rijswijk, Netherlands

[4] ViroClinics BV, NL-3000 DR Rotterdam, Netherlands

[5] Bavarian Nord GmbH, D-82152 Martinsried, Germany

来源：

JOURNAL OF VIROLOGY | 2005年 / 79卷 / 12期

关键词：

D O I：

10.1128/JVI.79.12.7845-7851.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The use of classical smallpox vaccines based on vaccinia virus (W) is associated with severe complications in both naive and immune individuals. Modified vaccinia virus Ankara (WVA), a highly attenuated replication-deficient strain of W, has been proven to be safe in humans and immunocompromised animals, and its efficacy against smallpox is currently being addressed. Here we directly compare the efficacies of MVA alone and in combination with classical W-based vaccines in a cynomolgus macaque monkeypox model. The MVA-based smallpox vaccine protected macaques against a lethal respiratory challenge with monkeypox virus and is therefore an important candidate for the protection of humans against smallpox.

引用

页码：7845 / 7851

页数：7

共 24 条

[1]

Amorosa VK, 2003, CLIN INFECT DIS, V37, P426, DOI 10.1086/375823

[2] Progressive vaccinia [J].

Bray, M ;

Wright, ME .

CLINICAL INFECTIOUS DISEASES, 2003, 36 (06) :766-774

[3] THE CONFIRMATION AND MAINTENANCE OF SMALLPOX ERADICATION [J].

BREMAN, JG ;

ARITA, I .

NEW ENGLAND JOURNAL OF MEDICINE, 1980, 303 (22) :1263-1273

[4] Highly attenuated modified vaccinia virus Ankara replicates in baby hamster kidney cells, a potential host for virus propagation, but not in various human transformed and primary cells [J].

Drexler, I ;

Heller, K ;

Wahren, B ;

Erfle, V ;

Sutter, G .

JOURNAL OF GENERAL VIROLOGY, 1998, 79 :347-352

[5] Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox [J].

Earl, PL ;

Americo, JL ;

Wyatt, LS ;

Eller, LA ;

Whitbeck, JC ;

Cohen, GH ;

Eisenberg, RJ ;

Hartmann, CJ ;

Jackson, DL ;

Kulesh, DA ;

Martinez, MJ ;

Miller, DM ;

Mucker, EM ;

Shamblin, JD ;

Zwiers, SH ;

Huggins, JW ;

Jahrling, PB ;

Moss, B .

NATURE, 2004, 428 (6979) :182-185

[6] Detection of smallpox virus DNA by LightCycler PCR [J].

Espy, MJ ;

Cockerill, FR ;

Meyer, RF ;

Bowen, MD ;

Poland, GA ;

Hadfield, TL ;

Smith, TF .

JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (06) :1985-1988

[7] Dendritic cells from mice neonatally vaccinated with modified vaccinia virus Ankara transfer resistance against herpes simplex virus type I to naive one-week-old mice [J].

Franchini, M ;

Hefti, H ;

Vollstedt, S ;

Glanzmann, B ;

Riesen, M ;

Ackermann, M ;

Chaplin, P ;

Shortman, K ;

Suter, M .

JOURNAL OF IMMUNOLOGY, 2004, 172 (10) :6304-6312

[8] US military smallpox vaccination program experience [J].

Grabenstein, JD ;

Winkenwerder, W .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (24) :3278-3282

[9] Smallpox as a biological weapon - Medical and public health management [J].

Henderson, DA ;

Inglesby, TV ;

Bartlett, JG ;

Ascher, MS ;

Eitzen, E ;

Jahrling, PB ;

Hauer, J ;

Layton, M ;

McDade, J ;

Osterholm, MT ;

O'Toole, T ;

Parker, G ;

Perl, T ;

Russell, PK ;

Tonat, K .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (22) :2127-2137

[10]

Kemper Alex R, 2002, Eff Clin Pract, V5, P84

← 1 2 3 →