Role of PPAR-γ2 polymorphisms in bodyweight regulation

被引：4

作者：

Ochoa, Maria C. ^{[1
]}

Razquin, Cristina ^{[1
]}

Martinez-Gonzalez, Miguel Angel ^{[1
]}

Marti, Amelia ^{[1
]}

Martinez, J. Alfredo ^{[1
]}

机构：

[1] Univ Navarra, Dept Nutr & Food Sci, Pamplona 31008, Navarra, Spain

来源：

FUTURE LIPIDOLOGY | 2008年 / 3卷 / 01期

关键词：

obesity; polymorphism; PPAR; Pro12Ala;

D O I：

10.2217/17460875.3.1.31

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peroxisome proliferator-activated receptor (PPAR)-gamma 2 is an adipose tissue-specific nuclear hormone receptor that regulates adipocytes differentiation and fat metabolism through a complex program concerning gene expression. This transcription factor, which is coded by the PPARG gene, located at the 3p25 region of the genome, appears to play an important role in bodyweight regulation. There are several polymorphisms in this gene that modulate the PPAR-gamma 2 function, which could also be associated with body weight and obesity. The Pro12Ala substitution is the most studied polymorphism of the PPARG gene. In this article, studies of the Pro12Ala variant and its association with obesity, including observational epidemiologic studies, gene-gene and gene-environment interaction studies as well as trials with dietary interventions are reviewed.

引用

页码：31 / 41

页数：11

共 89 条

[11] Energy balance and food intake:: The role of PPARγ gene polymorphisms [J].

Cecil, Joanne E. ;

Watt, Peter ;

Palmer, Colin N. ;

Hetherington, Marion .

PHYSIOLOGY & BEHAVIOR, 2006, 88 (03) :227-233

[12]

Chen TJ, 2007, BIOMED ENVIRON SCI, V20, P99

[13] The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes [J].

Clement, K ;

Hereberg, S ;

Passinge, B ;

Galan, P ;

Varroud-Vial, M ;

Shuldiner, AR ;

Beamer, BA ;

Charpentier, G ;

Guy-Grand, B ;

Froguel, P ;

Vaisse, C .

INTERNATIONAL JOURNAL OF OBESITY, 2000, 24 (03) :391-393

[14] The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans [J].

Cole, SA ;

Mitchell, BD ;

Hsueh, WC ;

Pineda, P ;

Beamer, BA ;

Shuldiner, AR ;

Comuzzie, AG ;

Blangero, J ;

Hixson, JE .

INTERNATIONAL JOURNAL OF OBESITY, 2000, 24 (04) :522-524

[15] Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor γ interactively influence insulin sensitivity and body composition in males [J].

Damcott, CM ;

Moffett, SP ;

Feingold, E ;

Barmada, MM ;

Marshall, JA ;

Hamman, RF ;

Ferrell, RE .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2004, 53 (03) :303-309

[16] A possible association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ2 gene with obesity in native Java']Javanese in Indonesia [J].

Danawati, CW ;

Nagata, M ;

Moriyama, H ;

Hara, K ;

Yasuda, H ;

Nakayama, M ;

Kotani, R ;

Yamada, K ;

Sakata, A ;

Kurohara, M ;

Wiyono, P ;

Asdie, H ;

Sakaue, M ;

Taniguchi, H ;

Yokono, K .

DIABETES-METABOLISM RESEARCH AND REVIEWS, 2005, 21 (05) :465-469

[17] A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity [J].

Deeb, SS ;

Fajas, L ;

Nemoto, M ;

Pihlajamäki, J ;

Mykkänen, L ;

Kuusisto, J ;

Laakso, M ;

Fujimoto, W ;

Auwerx, J .

NATURE GENETICS, 1998, 20 (03) :284-287

[18] Haplotype analysis of the PPARγ Pro12Ala and C1431T variants reveals opposing associations with body weight -: art. no. 21 [J].

Doney, A ;

Fischer, B ;

Frew, D ;

Cumming, A ;

Flavell, DM ;

World, M ;

Montgomery, HE ;

Boyle, D ;

Morris, A ;

Palmer, CNA .

BMC GENETICS, 2002, 3 (1)

[19] Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated receptor-γ2 (PPAR-γ2):: divergent modulating effects on body mass index in obese and lean Caucasian men [J].

Ek, J ;

Urhammer, SA ;

Sorensen, TIA ;

Andersen, T ;

Auwerx, J ;

Pedersen, O .

DIABETOLOGIA, 1999, 42 (07) :892-895

[20] The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 gene on insulin sensitivity and insulin metabolism interact with size at birth [J].

Eriksson, JG ;

Lindi, V ;

Uusitupa, M ;

Forsén, TJ ;

Laakso, M ;

Osmond, C ;

Barker, DJP .

DIABETES, 2002, 51 (07) :2321-2324

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