Genetics of nicotine dependence and pharmacotherapy

被引：65

作者：

Lessov-Schlaggar, Christina N. ^{[1
]}

Pergadia, Michele L. ^{[2
]}

Khroyan, Taline V. ^{[1
]}

Swan, Gary E. ^{[1
]}

机构：

[1] SRI Int, Ctr Hlth Sci, Menlo Pk, CA 94025 USA

[2] Washington Univ, Sch Med, St Louis, MO USA

来源：

BIOCHEMICAL PHARMACOLOGY | 2008年 / 75卷 / 01期

关键词：

phenotype refinement; genes; environment; comorbidity; pharmacogenetics; transdisciplinary;

D O I：

10.1016/j.bcp.2007.08.018

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nicotine dependence is substantially heritable. Several regions across the genome have been implicated in containing genes that confer liability to nicotine dependence and variation in individual genes has been associated with nicotine dependence. Smoking cessation measures are also heritable, and measured genetic variation is associated with nicotine dependence treatment efficacy. Despite significant strides in the understanding of the relative contribution of genetic and environmental factors to nicotine dependence and treatment, emergent challenges necessitate interdisciplinary coordinated effort for effective problem solving. These challenges include refinement of the nicotine dependence phenotype, better understanding of the dynamic interplay between genes and environment in nicotine dependence etiology, application and development of molecular and statistical methodology that can adequately address vast amounts of data, and continuous translational cross-talk. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：178 / 195

页数：18

共 240 条

[41] Self-administered and noncontingent nicotine enhance reinforced operant responding in rats: impact of nicotine dose and reinforcement schedule [J].

Chaudhri, Nadia ;

Caggiula, Anthony R. ;

Donny, Eric C. ;

Booth, Sheri ;

Gharib, Maysa ;

Craven, Laure ;

Palmatier, Matthew I. ;

Liu, Xiu ;

Sved, Alan F. .

PSYCHOPHARMACOLOGY, 2007, 190 (03) :353-362

[42] No interaction between the serotonin transporter polymorphism (5-HTTLPR) and childhood adversity or recent stressful life events on symptoms of depression: Results from two community surveys [J].

Chipman, P. ;

Jorm, A. F. ;

Prior, M. ;

Sanson, A. ;

Smart, D. ;

Tan, X. ;

Easteal, S. .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2007, 144B (04) :561-565

[43]

CHORBOV VM, 2007, AM J MED GENET B

[44] Varenicline:: An α4β2 nicotinic receptor partial agonist for smoking cessation [J].

Coe, JW ;

Brooks, PR ;

Vetelino, MG ;

Wirtz, MC ;

Arnold, EP ;

Huang, JH ;

Sands, SB ;

Davis, TI ;

Lebel, LA ;

Fox, CB ;

Shrikhande, A ;

Heym, JH ;

Schaeffer, E ;

Rollema, H ;

Lu, Y ;

Mansbach, RS ;

Chambers, LK ;

Rovetti, CC ;

Schulz, DW ;

Tingley, FD ;

O'Neill, BT .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (10) :3474-3477

[45] Association of catechol-O-methyltransferase with smoking cessation in two independent studies of women [J].

Colilla, S ;

Lerman, C ;

Shields, PG ;

Jepson, C ;

Rukstalis, M ;

Berlin, J ;

DeMichele, A ;

Bunin, G ;

Strom, BL ;

Rebbeck, TR .

PHARMACOGENETICS AND GENOMICS, 2005, 15 (06) :393-398

[46] SELECTIVE DOPAMINE ANTAGONISTS REDUCE NICOTINE SELF-ADMINISTRATION [J].

CORRIGALL, WA ;

COEN, KM .

PSYCHOPHARMACOLOGY, 1991, 104 (02) :171-176

[47]

COTTLER LB, 1995, DRUG ALCOHOL DEPEN, V38, P59, DOI 10.1016/0376-8716(94)01091-X

[48]

COTTLER LB, 1995, DRUG ALCOHOL DEPEN, V38, P71

[49] Interaction between variation in the D2 dopamine receptor (DRD2) and the neuronal calcium sensor-1 (FREQ) genes in predicting response to nicotine replacement therapy for tobacco dependence [J].

Dahl, J. P. ;

Jepson, C. ;

Levenson, R. ;

Wileyto, E. P. ;

Patterson, F. ;

Berrettini, W. H. ;

Lerman, C. .

PHARMACOGENOMICS JOURNAL, 2006, 6 (03) :194-199

[50] Molecular and cellular aspects of nicotine abuse [J].

Dani, JA ;

Heinemann, S .

NEURON, 1996, 16 (05) :905-908

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