Rare trisubstituted sesquiterpenes daucanes from the wild Daucus carota

被引：32

作者：

Ahmed, AA ^{[1
]}

Bishr, MM

El-Shanawany, MA

Attia, EZ

Ross, SA

Paré, PW

机构：

[1] Menia Univ, Dept Chem, Fac Sci, Menia 61519, Egypt

[2] Menia Univ, Fac Pharm, Dept Pharmacognosy, Menia 61519, Egypt

[3] Assiut Univ, Fac Pharm, Dept Pharmacognosy, Assiut, Egypt

[4] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, Nat Ctr Nat Prod Res, University, MS 38677 USA

[5] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

来源：

PHYTOCHEMISTRY | 2005年 / 66卷 / 14期

关键词：

Daucus carota ssp carota; Apiaceae; daucane sesquiterpenes; sesquiterpene coumarin; polyacetylene; antibacterial;

D O I：

10.1016/j.phytochem.2005.05.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical and biological investigation of the roots of the wild Daucus carota ssp. carota afforded three new and four known compounds, including four sesquiterpenes daucane esters (1 3 [new]. and 4), One polyacetylene (5), One sesquiterpene coumarin (6). and sitosterol glucoside. The structures of the new compounds were determined by comprehensive NMR Studies, including DEPT, COSY, NOESY, HMQC and HMBC analyses. Based on an agar diffusion assay, 1, 2 and 4-6 were screened and found to contain a range of low antibacterial activities against four gram positive (Staphylococeus aureus. Streptomyces scabies, Bacillus subtilus, Bacillus cereus) and two gram negative species (Pseudomonas aeruginosa, Escherichia coli) as well as antifungal against Fusarium oxysporum and Aspergillus niger using cup agar diffusion assay. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1680 / 1684

页数：5

共 23 条

[1] DAUCANES AND OTHER CONSTITUENTS FROM FERULA-SINAICA [J].