The oxytocinase subfamily of M1 aminopeptidases

被引：145

作者：

Tsujimoto, M ^{[1
]}

Hattori, A ^{[1
]}

机构：

[1] RIKEN, Lab Cellular Biochem, Wako, Saitama 3510198, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS | 2005年 / 1751卷 / 01期

关键词：

aminopeptidase; antigen presentation; glucose transporter 4; M1; family; oxytocinase subfamily;

D O I：

10.1016/j.bbapap.2004.09.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The placental leucine aminopeptidase (P-LAP), adipocyte-derived leucine aminopeptidase (A-LAP) and leukocyte-derived aminopeptidase (L-RAP) belong to one distinct group of the M I family of amimopeptidases, which we term the "Oxytocinase subfamily", They share HEXXH(X)(18)E Zn-binding and GAMEN motifs essential for the enzymatic activities. Intracellular localization is the characteristic feature of the subfamily members. While P-LAP is translocated from intracellular vesicles to plasma membrane in a stimulus-dependent manner, both A-LAP and L-RAP are retained in the endoplasmic reticulum. They contain sequences necessary for the specific localization in the cell. It is getting evident that the subfamily members play important roles in the maintenance of homeostasis including maintenance of normal pregnancy, memory retention, blood pressure regulation and antigen presentation. In this review, current situation of this newly identified subfamily is summarized. (c) 2004 Elsevier B.V. All rights reserved.

引用

页码：9 / 18

页数：10

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