Localization of tumour necrosis factor-α converting enzyme in normal human skin

被引：12

作者：

Kawaguchi, M ^{[1
]}

Mitsuhashi, Y ^{[1
]}

Kondo, S ^{[1
]}

机构：

[1] Yamagata Univ, Sch Med, Dept Dermatol, Yamagata 9909585, Japan

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 2004年 / 29卷 / 02期

关键词：

D O I：

10.1111/j.1365-2230.2004.01455.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The tumour necrosis factor (TNF)-alpha converting enzyme (TACE) is a metalloproteinase-disintegrin that releases soluble TNF-alpha from cells by cleaving within the extracellular domain of membrane-bound pro-TNF-alpha. TACE knockout mice display a range of epithelial abnormalities. However, the localization of TACE in normal human skin is unclear. In this study, we examined the expression of TACE in normal skin by immunohistochemical analysis. The expression of TACE was seen throughout all layers of the epidermis, the hair follicles, eccrine ducts and glands, and sebaceous glands. There was also staining of blood vessels in the dermis. In particular, TACE was localized predominantly in mast cells, suggesting that these cells are an important source of TNF-alpha.

引用

页码：185 / 187

页数：3

共 10 条

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