Current status and future prospects of transforming growth factor-β as a potential prognostic and therapeutic target in the treatment of breast cancer

被引：11

作者：

Amerizadeh, Forouzan ^{[1
]}

Bahrami, Afsane ^{[2
]}

Khazaei, Majid ^{[1
]}

Hesari, AmirReza ^{[1
]}

Rezayi, Majid ^{[1
]}

Talebian, Sahar ^{[3
]}

Maftouh, Mona ^{[1
]}

Moetamani-Ahmadi, Mehrdad ^{[1
]}

Seifi, Sima ^{[1
]}

Shahidsales, Soodabeh ^{[3
]}

Joudi-Mashhad, Mona ^{[3
]}

Ferns, Gordon A. ^{[4
]}

Ghasemi, Faezeh ^{[2
]}

Avan, Amir ^{[1
,3
]}

机构：

[1] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran

[2] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran

[3] Mashhad Univ Med Sci, Canc Res Ctr, Mashhad, Iran

[4] Brighton & Sussex Med Sch, Div Med Educ, Brighton, E Sussex, England

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2019年 / 120卷 / 05期

关键词：

breast cancer; prognostic biomarker; transforming growth factor-beta; EPITHELIAL-MESENCHYMAL TRANSITION; SUPERFAMILY SIGNALING PATHWAYS; TGF-BETA; TRANSCRIPTION FACTOR; TUMOR-SUPPRESSOR; MAMMARY-TUMOR; BONE METASTASIS; II RECEPTOR; CELLS; INHIBITION;

D O I：

10.1002/jcb.27831

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The transforming growth factor-beta (TGF-beta) signaling pathway is one of the important pathways involved in the cancer cell proliferation, invasion, migration, angiogenesis, apoptosis, as well as in metastasis by agitation or invasion of metastasis-related factors, including matrix metalloproteinase (MMP), epithelial-to-mesenchymal transition (EMT), tumor microenvironment (TME), cancer stem cells (CSCs), and cell adhesion molecules (CAMs). These data suggest its potential value as a therapeutic object in the treatment of malignancies including breast cancer. Several pharmacological approaches have been established to suppress TGF-beta pathway; such as vaccines, small molecular inhibitors, antisense oligonucleotides, and monoclonal antibodies. Some of these are now approved by the US Food and Drug Administration for targeting the TGF-beta signaling pathway. This study attempts to summarize the current data about the functions of TGF-beta in cancer cells, and their probable application in the cancer therapy with a specific emphasis on recent preclinical and clinical research in the treatment of breast cancer and its prognostic value.

引用

页码：6962 / 6971

页数：10

共 118 条

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