The Therapeutic Potential of Targeting Tumor Microenvironment in Breast Cancer: Rational Strategies and Recent Progress

被引：58

作者：

Bahrami, Afsane ^{[1
,2
,3
]}

Hassanian, Seyed Mahdi ^{[2
,4
]}

Khazaei, Majid ^{[5
]}

Hasanzadeh, Malihe ^{[6
]}

Shahidsales, Soodabeh ^{[7
]}

Maftouh, Mina ^{[2
]}

Ferns, Gordon A. ^{[8
]}

Avan, Amir ^{[2
,7
]}

机构：

[1] Mashhad Univ Med Sci, Dept Modern Sci & Technol, Fac Med, Mashhad, Iran

[2] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran

[3] Mashhad Univ Med Sci, Student Res Comm, Fac Med, Mashhad, Iran

[4] Mashhad Univ Med Sci, Sch Med, Dept Med Biochem, Mashhad, Iran

[5] Mashhad Univ Med Sci, Dept Physiol, Fac Med, Mashhad, Iran

[6] Mashhad Univ Med Sci, Dept Gynecol Oncol, Woman Hlth Res Ctr, Mashhad, Iran

[7] Mashhad Univ Med Sci, Canc Res Ctr, Mashhad, Iran

[8] Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PH, Sussex, England

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2018年 / 119卷 / 01期

关键词：

BREAST CANCER; TUMOR MICROENVIRONMENT; SRTOMA; FIBROBLAST; MACROPHAGE; MESENCHYMAL STEM-CELLS; MAMMARY ADIPOGENESIS; GOLD NANOPARTICLES; ONCOLYTIC VIRUSES; ANTICANCER DRUGS; ZOLEDRONIC ACID; T-CELLS; MACROPHAGES; METASTASIS; FIBROBLASTS;

D O I：

10.1002/jcb.26183

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The tumor microenvironment (TME) is cellular environment in addition to harboring carcinoma cells, consists of different components (e.g., blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, lymphocytes, signaling molecules, and the extracellular matrix) that have an essential role on drug activity and efficacy. There is growing body of evidence showing its involvement in the progression and metastasis of different cancers, including breast cancer (BC). These observations provide a proof of concept of targeting TME compartments as a novel potential therapeutic approach in treatment of this malignancy, which is the main interested for current review. J. Cell. Biochem. 119: 111-122, 2018. (c) 2017 Wiley Periodicals, Inc.

引用

页码：111 / 122

页数：12

共 112 条

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