Clinical Significance and Prognosis Value of Wnt Signaling Pathway in Cervical Cancer

被引：89

作者：

Bahrami, Afsane ^{[1
]}

Hasanzadeh, Malihe ^{[2
]}

ShahidSales, Soodabeh ^{[3
]}

Yousefi, Zohre ^{[2
]}

Kadkhodayan, Sima ^{[2
]}

Farazestanian, Marjaneh ^{[2
]}

Joudi Mashhad, Mona ^{[3
]}

Gharib, Masoumeh ^{[4
]}

Mahdi Hassanian, Seyed ^{[5
,6
]}

Avan, Amir ^{[6
]}

机构：

[1] Mashhad Univ Med Sci, Dept Modern Sci & Technol, Fac Med, Mashhad, Iran

[2] Mashhad Univ Med Sci, Dept Gynecol Oncol, Woman Hlth Res Ctr, Fac Med, Mashhad, Iran

[3] Mashhad Univ Med Sci, Canc Res Ctr, Mashhad, Iran

[4] Mashhad Univ Med Sci, Dept Pathol, Fac Med, Mashhad, Iran

[5] Mashhad Univ Med Sci, Dept Med Biochem, Fac Med, Mashhad, Iran

[6] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2017年 / 118卷 / 10期

关键词：

CERVICAL CANCER; PATIENTS; WNT PATHWAY; WNT/BETA-CATENIN PATHWAY; BETA-CATENIN; PROMOTER METHYLATION; EXPRESSION; ACTIVATION; GENE; PROLIFERATION; INVASION; CELLS; E6;

D O I：

10.1002/jcb.25992

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Cervical cancer is among the most commonly diagnosed cancer in women, supporting the need for identification of novel prognostic and predictive biomarkers to predict the risk of developing of this malignancy or predict the prognosis of patients. Against this background, the activation of the Wingless-type (Wnt)/beta-catenin pathway has been suggested as the main dysregulated pathways, which is involved in the multistep process of cervical carcinogenesis, suggesting its value as a potential biomarker or therapeutic target. The aimof current review is to give an overview about the potential application of WNT pathway and its value which is differentially expressed in cervical cancer versus non-tumorigenic tissue as biomarker for risk stratification and predict the prognosis of patients with cervical cancer. (C) 2017 Wiley Periodicals, Inc.

引用

收藏

页码：3028 / 3033

页数：6

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