New agents to combat malaria

被引：20

作者：

Beeson, JG ^{[1
]}

Winstanley, PA

McFadden, GI

Brown, GV

机构：

[1] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Parkville, Vic 3052, Australia

[2] Univ Liverpool, Dept Pharmacol & Therapeut, Liverpool L69 3BX, Merseyside, England

[3] Univ Melbourne, Sch Bot, Plant Cell Biol Res Ctr, Parkville, Vic 3052, Australia

来源：

NATURE MEDICINE | 2001年 / 7卷 / 02期

关键词：

D O I：

10.1038/84573

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Triclosan, an antibacterial agent found in mouthwashes, acne medicines and deodorants, also prevents the growth of Plasmodium falciparum. If properly developed, this type II fatty acid biosynthesis inhibitor may be a promising new antimalarial agent (pages 167–173).

引用

页码：149 / 150

页数：2

共 9 条

[1] Triclosan: Applications and safety [J].

Bhargava, HN ;

Leonard, PA .

AMERICAN JOURNAL OF INFECTION CONTROL, 1996, 24 (03) :209-218

[2]

GOODMAN C, 2000, STRATEGIC RES SERIES, V1

[3] Broad spectrum antimicrobial biocides target the FabI component of fatty acid synthesis [J].

Heath, RJ ;

Yu, YT ;

Shapiro, MA ;

Olson, E ;

Rock, CO .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (46) :30316-30320

[4] Mechanism of triclosan inhibition of bacterial fatty acid synthesis [J].

Heath, RJ ;

Rubin, JR ;

Holland, DR ;

Zhang, EL ;

Snow, ME ;

Rock, CO .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (16) :11110-11114

[5] Apicomplexan plastids as drug targets [J].

McFadden, GI ;

Roos, DS .

TRENDS IN MICROBIOLOGY, 1999, 7 (08) :328-333

[6]

SIDDIQUI WH, 1979, J ENVIRON PATHOL TOX, V2, P861

[7] Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum [J].

Surolia, N ;

Surolia, A .

NATURE MEDICINE, 2001, 7 (02) :167-173

[8] Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum [J].

Waller, RF ;

Keeling, PJ ;

Donald, RGK ;

Striepen, B ;

Handman, E ;

Lang-Unnasch, N ;

Cowman, AF ;

Besra, GS ;

Roos, DS ;

McFadden, GI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (21) :12352-12357

[9]

World Health Organization, 1997, Weekly Epidemiological Record, V72, P269

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