Cancer genetics of epigenetic genes

被引：186

作者：

Miremadi, Ahmad

Oestergaard, Mikkel Z.

Pharoah, Paul D. P.

Caldas, Carlos

机构：

[1] Univ Cambridge, Canc Genom Program, Dept Oncol, Hutchison MRC Res Ctr, Cambridge, England

[2] Univ Cambridge, Dept Publ Hlth, Strangeways Res Labs, Cambridge, England

来源：

HUMAN MOLECULAR GENETICS | 2007年 / 16卷

关键词：

D O I：

10.1093/hmg/ddm021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cancer epigenome is characterised by specific DNA methylation and chromatin modification patterns. The proteins that mediate these changes are encoded by the epigenetics genes here defined as: DNA methyltransferases (DNMT), methyl-CpG-binding domain (MBID) proteins, histone acetyltransferases (HAT), histone deacetylases (HDAC), histone methyltransferases (HMT) and histone demethylases. We review the evidence that these genes can be targeted by mutations and expression changes in human cancers.

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页码：R28 / R49

页数：22

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