Association of t(9;11)-MLL AF9 and trisomy 8 in an AML-M5 preceded by pancytopenia

被引:3
作者
Anguita, E
Barrio, CG
González, FA
Ferro, MT
del Potro, E
Ropero, P
Villegas, A
机构
[1] Hosp Clin San Carlos, Serv Hematol & Hemoterapia, Dept Hematol, Madrid 28040, Spain
[2] Hosp Ramon y Cajal, Dept Genet, E-28034 Madrid, Spain
关键词
D O I
10.1016/S0165-4608(99)00260-5
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The implication of MLL gene rearrangements in the prognosis of acute myeloblastic leukemia is an issue of considerable current interest. We report a case of a young man who initially presented with a pancytopenia and went on 50 develop a highly-aggressive acute myeloblastic leukemia. At this time, the karyotypic study revealed trisomy 8, a t(9;11) was demonstrated by fluorescence in situ hybridization (FISH) and the MLL/AF4 rearrangement by reverse transcriptase-polymerase chain reaction (RT-PCR). (C) 2000 Elsevier Science Inc. All rights reserved.
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页码:144 / 147
页数:4
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