The pathology of cellular anti-stress mechanisms: A new frontier

被引：20

作者：

Macario, AJL

de Macario, EC

机构：

[1] SUNY Albany, New York State Dept Hlth, Div Mol Med, Wadsworth Ctr, Albany, NY 12201 USA

[2] SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Albany, NY 12201 USA

来源：

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS | 2004年 / 7卷 / 04期

关键词：

heat-shock proteins (Hsp); molecular chaperones; stress; anti-stress mechanisms; protein folding; chaperonopathies;

D O I：

10.1080/10253890400019706

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Exposure to stressors is an omnipresent variable for all living organisms, which have evolved anti-stress mechanisms to deal with the consequences of stress. The chaperoning systems are among these mechanisms, and their central components are the molecular chaperones that play important roles in protein biogenesis. Recent data suggest that failure of the chaperoning systems due to defective chaperones. for example, leads to pathology. Consequently, medical researchers and practitioners must now also consider the chaperoning systems, both as potentially major players in pathogenesis and as diagnostic-prognostic indicators.

引用

收藏

页码：243 / 249

页数：7

相关论文

共 102 条

[91] Aging and molecular chaperones [J].

Soti, C ;

Csermely, P .

EXPERIMENTAL GERONTOLOGY, 2003, 38 (10) :1037-1040

[92] Heat shock protein 27 gene: Chromosomal and molecular location and relationship to Williams syndrome [J].

Stock, AD ;

Spallone, PA ;

Dennis, TR ;

Netski, D ;

Morris, CA ;

Mervis, CB ;

Hobart, HH .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2003, 120A (03) :320-325

[93] PROTEIN-SYNTHESIS IN SALIVARY-GLANDS OF DROSOPHILA-MELANOGASTER - RELATION TO CHROMOSOME PUFFS [J].

TISSIERES, A ;

MITCHELL, HK ;

TRACY, UM .

JOURNAL OF MOLECULAR BIOLOGY, 1974, 84 (03) :389-+

[94] The role of structural disorder in the function of RNA and protein chaperones [J].

Tompa, P ;

Csermely, P .

FASEB JOURNAL, 2004, 18 (11) :1169-1175

[95] Mechanisms of protein import into mitochondria [J].

Truscott, KN ;

Brandner, K ;

Pfanner, N .

CURRENT BIOLOGY, 2003, 13 (08) :R326-R337

[96] A missense mutation in the αB-crystallin chaperone gene causes a desmin-related myopathy [J].

Vicart, P ;

Caron, A ;

Guicheney, P ;

Li, ZL ;

Prévost, MC ;

Faure, A ;

Chateau, D ;

Chapon, F ;

Tomé, F ;

Dupret, JM ;

Paulin, D ;

Fardeau, M .

NATURE GENETICS, 1998, 20 (01) :92-95

[97] The J-protein family: modulating protein assembly, disassembly and translocation [J].

Walsh, P ;

Bursac, D ;

Law, YC ;

Cyr, D ;

Lithgow, T .

EMBO REPORTS, 2004, 5 (06) :567-571

[98] MAMMALIAN STRESS RESPONSE - CELL PHYSIOLOGY, STRUCTURE-FUNCTION OF STRESS PROTEINS, AND IMPLICATIONS FOR MEDICINE AND DISEASE [J].

WELCH, WJ .

PHYSIOLOGICAL REVIEWS, 1992, 72 (04) :1063-1081

[99] Truncation of βA3/A1-crystallin during aging of the bovine lens;: Possible implications for lens optical quality [J].

Werten, PJL ;

Vos, E ;

De Jong, W .

EXPERIMENTAL EYE RESEARCH, 1999, 68 (01) :99-103

[100] Analysis of heat-shock protein 70 gene polymorphisms and the risk of Parkinson's disease [J].

Wu, YR ;

Wang, CK ;

Chen, CM ;

Hsu, YY ;

Lin, SJ ;

Lin, YY ;

Fung, HC ;

Chang, KH ;

Lee-Chen, GJ .

HUMAN GENETICS, 2004, 114 (03) :236-241

← 2 3 4 5 6 7 8 9 10 11 →