Interleukin-28B Genotyping by Melt-Mismatch Amplification Mutation Assay PCR Analysis Using Single Nucleotide Polymorphisms rs12979860 and rs8099917, a Useful Tool for Prediction of Therapy Response in Hepatitis C Patients

被引：16

作者：

Fonseca-Coronado, Salvador ^{[2
]}

Vaughan, Gilberto ^{[1
]}

Yolanda Cruz-Rivera, Mayra ^{[3
]}

Carlos Carpio-Pedroza, Juan ^{[1
]}

Ruiz-Tovar, Karina ^{[1
]}

Alberto Ruiz-Pacheco, Juan ^{[1
]}

Escobar-Gutierrez, Alejandro ^{[1
]}

机构：

[1] Inst Diagnost & Referencia Epidemiol, Dept Invest Inmunol, Secretaria Salud, Mexico City 11340, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Unidad Invest Multidisciplinaria, Fac Estudios Super Cuautitlan, Mexico City 04510, DF, Mexico

[3] Univ Nacl Autonoma Mexico, Dept Microbiol & Parasitol, Fac Med, Mexico City 04510, DF, Mexico

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2011年 / 49卷 / 07期

关键词：

ANTIVIRAL THERAPY; GENETIC-VARIATION; MAMA-PCR; VIRUS; IL28B; PEGINTERFERON; INFECTION; CLEARANCE;

D O I：

10.1128/JCM.00877-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Several studies have identified associations between single nucleotide polymorphisms (SNPs) occurring near the interleukin-28B (IL-28B) gene and response to antiviral treatment among hepatitis C virus (HCV) patients. Here, we describe a reliable melt-mismatch amplification mutation assay (melt-MAMA) PCR-based genotyping method for IL-28B which can be used in the management of HCV patients, helping to better define the course of therapy.

引用

页码：2706 / 2710

页数：5

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