Chronic oxidative stress induces a tissue-specific reduction in telomere length in CAST/Ei mice

被引：97

作者：

Cattan, Valerie ^{[1
,2
]}

Mercier, Nathalie ^{[1
,2
]}

Gardner, Jeffrey P. ^{[3
]}

Regnault, Veronique ^{[2
,4
]}

Labat, Carlos ^{[1
,2
]}

Maki-Jouppila, Jenni ^{[1
,2
]}

Nzietchueng, Rosine ^{[1
,2
]}

Benetos, Athanase ^{[1
,2
]}

Kimura, Masayuki ^{[3
]}

Aviv, Abraham ^{[3
]}

Lacolley, Patrick ^{[1
,2
]}

机构：

[1] UHP Nancy, Fac Med, INSERM U684, F-54500 Vandoeuvre Les Nancy, France

[2] Henri Poincare Univ, F-54000 Nancy, France

[3] Univ Med & Dent New Jersey, Ctr Human Dev & Aging, New Jersey Med Sch, Newark, NJ 07103 USA

[4] INSERM U734, F-54500 Vandoeuvre Les Nancy, France

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2008年 / 44卷 / 08期

关键词：

telomere; mouse; tissue; oxidative stress; glutathione;

D O I：

10.1016/j.freeradbiomed.2008.01.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examine whether increased oxidative stress in vivo promotes telomere shortening in CAST/Ei mice. We explored the effects of L-buthionine sulfoximine treatment (BSO) on telomere length. BSO shortened telomere length in white fat, brown fat, skin, tail, and testis in concert with diminished tissue glutathione content, increased tissue carbonyl content, and increased plasma advanced oxidized protein products. Telomerase activity was mainly detected in testis but no reduction of telomerase activity was observed in response to BSO. In conclusion, BSO-mediated increase in systemic oxidative stress shortens telomeres in several tissues of the mouse. The variable effect of BSO treatment on telomere length in different tissue may result from their different adaptive antioxidative capacity. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：1592 / 1598

页数：7

共 34 条

[1] Telomeres and human somatic fitness [J].

Aviv, Abraham .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2006, 61 (08) :871-873

[2] The signals and pathways activating cellular senescence [J].

Ben-Porath, I ;

Weinberg, RA .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2005, 37 (05) :961-976

[3] Telomeres and telomerase: their mechanisms of action and the effects of altering their functions [J].

Blackburn, EH .

FEBS LETTERS, 2005, 579 (04) :859-862

[4] Ageing and telomeres: a study into organ- and gender-specific telomere shortening [J].

Cherif, H ;

Tarry, JL ;

Ozanne, SE ;

Hales, CN .

NUCLEIC ACIDS RESEARCH, 2003, 31 (05) :1576-1583

[5] Gene expression of energy and protein metabolism in hearts of hypertensive nitric oxide- or GSH-depleted mice [J].

Chon, H ;

Bluyssen, HAR ;

Holstege, FCP ;

Koomans, HA ;

Joles, JA ;

Braam, B .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2005, 513 (1-2) :21-33

[6] Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study [J].

Demissie, S. ;

Levy, D. ;

Benjamin, E. J. ;

Cupples, L. A. ;

Gardner, J. P. ;

Herbert, A. ;

Kimura, M. ;

Larson, M. G. ;

Meigs, J. B. ;

Keaney, J. F. ;

Aviv, A. .

AGING CELL, 2006, 5 (04) :325-330

[7] Characterization of blood pressure and morphological traits in cardiovascular-related organs in 13 different inbred mouse strains [J].

Deschepper, CF ;

Olson, JL ;

Otis, M ;

Gallo-Payet, N .

JOURNAL OF APPLIED PHYSIOLOGY, 2004, 97 (01) :369-376

[8] Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telornere shortening [J].

Duan, HM ;

Duan, HP ;

Zhang, ZY ;

Tong, TJ .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2005, 37 (07) :1407-1420

[9] Accelerated telomere shortening in response to life stress [J].

Epel, ES ;

Blackburn, EH ;

Lin, J ;

Dhabhar, FS ;

Adler, NE ;

Morrow, JD ;

Cawthon, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (49) :17312-17315

[10] Telomerase regulation and stem cell behaviour [J].

Flores, Ignacio ;

Benetti, Roberta ;

Blasco, Maria A. .

CURRENT OPINION IN CELL BIOLOGY, 2006, 18 (03) :254-260

← 1 2 3 4 →