Combined heterozygosity for methylenetetrahydrofolate reductase (MTHFR) mutations C677T and A1298C is associated with abruptio placentae but not with intrauterine growth restriction

被引：32

作者：

Gebhardt, GS

Scholtz, CL

Hillermann, R

Odendaal, HJ

机构：

[1] Fac Med, Dept Obstet & Gynaecol, ZA-7505 Tygerberg, South Africa

[2] Univ Stellenbosch, Tygerberg Hosp, Fac Med, Div Human Genet, ZA-7505 Tygerberg, South Africa

[3] MRC, Res Unit Perinatal Mortal, ZA-7505 Tygerberg, South Africa

来源：

EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 2001年 / 97卷 / 02期

关键词：

MTHFR combined heterozygosity; abruptio placentae;

D O I：

10.1016/S0301-2115(00)00540-6

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: This study was undertaken to investigate the involvement of MTHFR gene mutations C677T and A1298C implicated in vascular disease, in patients with abruptio placentae and intrauterine growth restriction (IUGR). Study Design: DNA was extracted from blood samples of 54 patients with placental vasculopathy (18 patients with abruptio placentae and 36 with IUGR) and 114 control patients and amplified by the polymerase chain reaction (PCR). The resulting fragments were subjected to restriction enzyme analysis and resolved by gel electrophoresis. Results: A significant association could be demonstrated between mutation A 1298C and both-abruptio placentae and IUGR. Combined heterozygosity for mutations C677T and A1298C was detected in 22.2% of abruptio placentae cases. Conclusions: Combined heterozygosity for MTHFR mutations C677T and A1298C may represent a genetic marker for abruptio placentae. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：174 / 177

页数：4