High-dose aspirin is neuroprotective in a rat focal ischemia model

被引：26

作者：

Berger, C ^{[1
]}

Xia, F ^{[1
]}

Schabitz, WR ^{[1
]}

Schwab, S ^{[1
]}

Grau, A ^{[1
]}

机构：

[1] Heidelberg Univ, Dept Neurol, D-69120 Heidelberg, Germany

来源：

BRAIN RESEARCH | 2004年 / 998卷 / 02期

关键词：

stroke; ischemia; aspirin; neuroprotection;

D O I：

10.1016/j.brainres.2003.11.049

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Acetylsalicylic acid (ASA) is neuroprotective through various pharmacological action sites. We used a temporary middle cerebral artery occlusion (tMCAO) model in 56 Wistar rats to assess whether repeated ASA injections at 30 min, 6 h, 1, 2, 3, and 4 days after stroke onset are neuroprotective. Animals were sacrificed 5 days after MCAO; infarct size was analyzed with 2,3,5-triphenyltetrazolium chloride staining. As compared to saline (164+/-13 mm(3), n=14), only repeated injections of 40 mg/kg ASA (79+/-18 mm(3), n=14, P=0.0029), but not of 20 mg/kg ASA (129+/-19 mm(3), n=15), reduced infarct volume significantly. No significant change was noted with 40 mg/kg ASA injected only once at 30 min after MCAO (117+/-16 mm(3), n=13). (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：237 / 242

页数：6

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