Farnesyltransferase inhibitors inhibit the growth of malaria parasites in vitro and in vivo

被引：73

作者：

Wiesner, J

Kettler, K

Sakowski, J

Ortmann, R

Katzin, AM

Kimura, EA

Silber, K

Klebe, G

Jomaa, H

Schlitzer, M

机构：

[1] Univ Munich, Dept Pharm, Zentrum Pharmaforsch, D-81377 Munich, Germany

[2] Univ Giessen, Inst Biochem, D-35392 Giessen, Germany

[3] Univ Sao Paulo, Inst Ciencias Biomed, BR-05508900 Sao Paulo, Brazil

[4] Univ Marburg, Inst Pharmazeut Chem, D-35032 Marburg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 02期

关键词：

drug design; enzyme inhibitors; farnesyltransferase; malaria; medicinal chemistry;

D O I：

10.1002/anie.200351169

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The inhibition of farnesyltransferase was recently suggested as a new strategy for malaria therapy. A class of farnesyltransferase inhibitors such as 1 has been prepared which have in vivo activity in a murine malaria model. These inhibitors significantly reduce the farnesylation of parasite proteins.

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收藏

页码：251 / 254

页数：4

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