Platelet interactions in thrombosis

被引:51
作者
Andrews, RK [1 ]
Gardiner, EE [1 ]
Shen, Y [1 ]
Berndt, MC [1 ]
机构
[1] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3168, Australia
关键词
thrombosis; platelets; adhesion receptors; GPIb-IX-V; GPVI;
D O I
10.1080/15216540310001649831
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Patho/physiological platelet aggregate ( thrombus) formation is initiated by engagement of platelet surface receptors, glycoprotein (GP) Ib-IX-V and GPVI that bind von Willebrand factor or collagen. Although beneficial in response to vascular injury by preventing blood loss ( haemostasis), platelet aggregation in a sclerotic coronary artery or other diseased blood vessel ( thrombosis) can cause thrombotic diseases like heart attack and stroke. At the molecular level, ligand interactions with GPIb-IX-V or GPVI trigger signalling responses, including elevation of cytosolic Ca2+, dissociation of calmodulin from their cytoplasmic domains, cytoskeletal actin-filament rearrangements, activation of src-family kinases or PI 3-kinase, and 'inside- out' activation of the integrin, alphaIIbbeta3 (GPIIb-IIIa), that binds von Willebrand factor or fibrinogen and mediates platelet aggregation. Furthermore, emerging evidence supports a topographical co-association of these receptors of the leucine-rich repeat family (GPIb-IX-V) and immunoglobulin superfamily ( GPVI) in an adhesive cluster or 'adhesosome'. This arrangement may underlie common mechanisms of initiating thrombus formation in haemostasis or thrombotic disease.
引用
收藏
页码:13 / 18
页数:6
相关论文
共 45 条
  • [11] The cytoplasmic domain of the platelet glycoprotein Ibα is phosphorylated at Serine 609
    Bodnar, RJ
    Gu, MY
    Li, ZY
    Englund, GD
    Du, XP
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (47) : 33474 - 33479
  • [12] Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser166 of glycoprotein Ibβ
    Bodnar, RJ
    Xi, XD
    Li, ZY
    Berndt, MC
    Du, XP
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (49) : 47080 - 47087
  • [13] Delineation of the region in the glycoprotein VI tail required for association with the Fc receptor γ-chain
    Bori-Sanz, T
    Inoue, KS
    Berndt, MC
    Watson, SP
    Tulasne, D
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (38) : 35914 - 35922
  • [14] Antithrombotic effect of platelet glycoprotein Ib-blocking monoclonal antibody Fab fragments in nonhuman primates
    Cauwenberghs, N
    Meiring, M
    Vauterin, S
    van Wyk, V
    Lamprecht, S
    Roodt, JP
    Novák, L
    Harsfalvi, J
    Deckmyn, H
    Kotzé, HF
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (05) : 1347 - 1353
  • [15] Modulation of α-thrombin function by distinct interactions with platelet glycoprotein Ib-α
    Celikel, R
    McClintock, RA
    Roberts, JR
    Mendolicchio, GL
    Ware, J
    Varughese, KI
    Ruggeri, ZM
    [J]. SCIENCE, 2003, 301 (5630) : 218 - 221
  • [16] Crystal structure of the GpIbα-thrombin complex essential for platelet aggregation
    Dumas, JJ
    Kumar, R
    Seehra, J
    Somers, WS
    Mosyak, L
    [J]. SCIENCE, 2003, 301 (5630) : 222 - 226
  • [17] Regulation of von Willebrand factor finding to the platelet glycoprotein Ib-IX by a membrane skeleton-dependent inside-out signal
    Englund, GD
    Bodnar, RJ
    Li, ZY
    Ruggeri, ZM
    Du, XP
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (20) : 16952 - 16959
  • [18] Glycoprotein Ib-V-IX, a receptor for von Willebrand factor, couples physically and functionally to the Fc receptor γ-chain, Fyn, and Lyn to activate human platelets
    Falati, S
    Edmead, CE
    Poole, AW
    [J]. BLOOD, 1999, 94 (05) : 1648 - 1656
  • [19] Filamin A binding to the cytoplasmic tail of glycoprotein Ibα regulates von Willebrand factor-induced platelet activation
    Feng, SJ
    Reséndiz, JC
    Lu, X
    Kroll, MH
    [J]. BLOOD, 2003, 102 (06) : 2122 - 2129
  • [20] Cytoplasmic domains of GpIbα and GpIbβ regulate 14-3-3ζ binding to GpIb/IX/V
    Feng, SJ
    Christodoulides, N
    Reséndiz, JC
    Berndt, MC
    Kroll, MH
    [J]. BLOOD, 2000, 95 (02) : 551 - 557