Antibacterial activity of black myrobalan (Terminalia chebula Retz) against Helicobacter pylori

被引：146

作者：

Malekzadeh, F

Ehsanifar, H

Shahamat, M

Levin, M

Colwell, RR

机构：

[1] Univ Maryland, Ctr Marine Biotechnol, Inst Biotechnol, Baltimore, MD 21202 USA

[2] Univ Tehran, Dept Microbiol & Biol Sci, Tehran, Iran

[3] Univ Maryland, Dept Cell & Mol Genet, College Pk, MD 20742 USA

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2001年 / 18卷 / 01期

关键词：

Helicobacter pylori; antibacterial activity; black myrobalan;

D O I：

10.1016/S0924-8579(01)00352-1

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The effect of ether, alcoholic and water extracts of black myrobalan (Teminalia chebula Retz) on Helicobactor pylori were examined using an agar diffusion method on Columbia Agar. Water extracts of black myrobalan showed significant antibacterial activity and had a minimum inhibitory concentration (MIC) and minimum bacteriocidal concentration (MBC) of 125 and 150 mg/l, respectively. The extract was active after autoclaving for 30 min at 121 degreesC. Plant powder (incorporated in agar) gave higher MIC and MBC values (150 and 175 mg/l, respectively). Water extracts of the black myrobalan at a concentration of 1-2.5 mg/ml inhibited urease activity of H. pylori. The results show that black myrobalan extracts contain a heat stable agent(s) with possible therapeutic potential. Other bacterial species were also inhibited by black myrobalan water extracts. (C) 2001 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

引用

页码：85 / 88

页数：4