Clonal evolution in cancer

被引：2200

作者：

Greaves, Mel ^{[1
]}

Maley, Carlo C. ^{[2
]}

机构：

[1] Inst Canc Res, Div Mol Pathol, Sutton SM2 5NG, Surrey, England

[2] Univ Calif San Francisco, Dept Surg, Helen Diller Family Comprehens Canc Ctr, Ctr Evolut & Canc, San Francisco, CA 94115 USA

来源：

NATURE | 2012年 / 481卷 / 7381期

关键词：

STEM-CELLS; BARRETTS-ESOPHAGUS; SOMATIC MUTATIONS; IN-SITU; LEUKEMIA; PROGRESSION; SELECTION; HETEROGENEITY; DIVERSITY; METASTASIS;

D O I：

10.1038/nature10762

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal architecture. Therapeutic intervention may destroy cancer clones and erode their habitats, but it can also inadvertently provide a potent selective pressure for the expansion of resistant variants. The inherently Darwinian character of cancer is the primary reason for this therapeutic failure, but it may also hold the key to more effective control.

引用

页码：306 / 313

页数：8

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