Programming of Erythromycin Biosynthesis by a Modular Polyketide Synthase

被引：52

作者：

Cane, David E. ^{[1
]}

机构：

[1] Brown Univ, Dept Chem, Providence, RI 02912 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2010年 / 285卷 / 36期

基金：

美国国家卫生研究院;

关键词：

ACYL CARRIER PROTEIN; FATTY-ACID SYNTHASE; BETA-KETOREDUCTASE DOMAINS; 6-DEOXYERYTHRONOLIDE-B SYNTHASE; SACCHAROPOLYSPORA-ERYTHRAEA; CRYSTAL-STRUCTURE; INTERMODULAR COMMUNICATION; MECHANISTIC ANALYSIS; 4-PRO-S HYDRIDE; MOLECULAR-BASIS;

D O I：

10.1074/jbc.R110.144618

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：27517 / 27523

页数：7

共 70 条

[31] Structure and mechanism of the 6-deoxyerythronolide B synthase [J].

Khosla, Chaitan ;

Tang, Yinyan ;

Chen, Alice Y. ;

Schnarr, Nathan A. ;

Cane, David E. .

ANNUAL REVIEW OF BIOCHEMISTRY, 2007, 76 :195-221

[32] Structures and Mechanisms of Polyketide Synthases [J].

Khosla, Chaitan .

JOURNAL OF ORGANIC CHEMISTRY, 2009, 74 (17) :6416-6420

[33] Revisiting the modularity of modular polyketide synthases [J].

Khosla, Chaitan ;

Kapur, Shiven ;

Cane, David E. .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2009, 13 (02) :135-143

[34] An efficient method for creation and functional analysis of libraries of hybrid type I polyketide synthases [J].

Kim, BS ;

Sherman, DH ;

Reynolds, KA .

PROTEIN ENGINEERING DESIGN & SELECTION, 2004, 17 (03) :277-284

[35] Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase [J].

Kim, CY ;

Alekseyev, VY ;

Chen, AY ;

Tang, YY ;

Cane, DE ;

Khosla, C .

BIOCHEMISTRY, 2004, 43 (44) :13892-13898

[36] The structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa [J].

Kimber, MS ;

Martin, F ;

Lu, YJ ;

Houston, S ;

Vedadi, M ;

Dharamsi, A ;

Fiebig, KM ;

Schmid, M ;

Rock, CO .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (50) :52593-52602

[37] Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism [J].

Komatsua, Mamoru ;

Uchiyama, Takuma ;

Omura, Satoshi ;

Cane, David E. ;

Ikeda, Haruo .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (06) :2646-2651

[38] Intermodular communication in modular polyketide synthases: Structural and mutational analysis of linker mediated protein-protein recognition [J].

Kumar, P ;

Li, Q ;

Cane, DE ;

Khosla, C .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (14) :4097-4102

[39] Prediction and Manipulation of the Stereochemistry of Enoylreduction in Modular Polyketide Synthases [J].

Kwan, David H. ;

Sun, Yuhui ;

Schulz, Frank ;

Hong, Hui ;

Popovic, Bojana ;

Sim-Stark, Joalice C. C. ;

Haydock, Stephen F. ;

Leadlay, Peter F. .

CHEMISTRY & BIOLOGY, 2008, 15 (11) :1231-1240

[40] Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units [J].

Lau, J ;

Fu, H ;

Cane, DE ;

Khosla, C .

BIOCHEMISTRY, 1999, 38 (05) :1643-1651

← 1 2 3 4 5 6 7 →