Differential Receptor Binding Affinities of Influenza Hemagglutinins on Glycan Arrays

被引：78

作者：

Liao, Hsin-Yu ^{[1
,2
]}

Hsu, Che-Hsiung ^{[1
,3
,4
]}

Wang, Shih-Chi ^{[1
,2
]}

Liang, Chi-Hui ^{[1
]}

Yen, Hsin-Yung ^{[1
,5
]}

Su, Ching-Yao ^{[1
,5
]}

Chen, Chien-Hung ^{[1
]}

Jan, Jia-Tsrong ^{[1
]}

Ren, Chien-Tai ^{[1
]}

Chen, Chung-Hsuan ^{[1
]}

Cheng, Ting-Jen R. ^{[1
]}

Wu, Chung-Yi ^{[1
]}

Wong, Chi-Huey ^{[1
,4
]}

机构：

[1] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

[2] Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 112, Taiwan

[3] Natl Tsing Hua Univ, Inst Bioinformat & Struct Biol, Hsinchu 300, Taiwan

[4] Acad Sinica, Taiwan Int Grad Program, Taipei, Taiwan

[5] Natl Taiwan Univ, Inst Biochem Sci, Taipei, Taiwan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 42期

关键词：

A/H2N2 VIRUS HEMAGGLUTININ; HUMAN L-SELECTIN; A-VIRUS; INTRACELLULAR-TRANSPORT; DISSOCIATION-CONSTANTS; BIOLOGICAL-ACTIVITIES; MICROARRAY ANALYSIS; LEWIS-X; GLYCOSYLATION; SPECIFICITY;

D O I：

10.1021/ja104657b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A library of 27 sialosides, including seventeen 2,3-linked and ten 2,6-linked glycans, has been prepared to construct a glycan array and used to profile the binding specificity of different influenza hemagglutinins (HA) subtypes, especially from the 2009 swine-originated H1N1 and seasonal influenza viruses. It was found that the HAs from the 2009 H1N1 and the seasonal Brisbane strain share similar binding profiles yet different binding affinities toward various alpha 2,6 sialosides. Analysis of the binding profiles of different HA subtypes indicate that a minimum set of 5 oligosaccharides can be used to differentiate influenza H1, H3, H5, H7, and H9 subtypes. In addition, the glycan array was used to profile the binding pattern of different influenza viruses. It was found that most binding patterns of viruses and HA proteins are similar and that glycosylation at Asn27 is essential for receptor binding.

引用

页码：14849 / 14856

页数：8

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