N2a and P2a chickens, resistant and susceptible to Marek's disease (MD), respectively, were used to examine relationships between major histocompatibility complex (MHC)-restricted cytotoxic T lymphocytes (CTL) and natural killer (NK)-like cell activity with resistance to infection with Marek's disease virus (MDV). Ten-day-old chickens were infected with MDV and euthanatized at selected times to evaluate for NK cell and MHC-restricted cytotoxicity. The N2a MDV-infected chickens had an early cell-mediated immune response characterized by a sustained NK-like cytotoxicity that coincided with a measurable MHC-cytotoxicity that was lower than controls. Although MHC-restricted and NK cell cytotoxicity was demonstrated in P2a MDV-infected chickens at 8 dpi, both abruptly decreased and remained low for the remainder of the 20-day experiment. The critical time point that may determine the resistance to MD appears to be within the first 2 weeks post-infection. Improvement of the chicken NK cell activity may be a good candidate for both selection and immunomodulation MD control programs. (C) 2003 Elsevier B.V. All rights reserved.
机构:
Cornell Univ, Coll Vet Med, Dept Immunol & Microbiol, Unit Avian Med, Ithaca, NY 14853 USACornell Univ, Coll Vet Med, Dept Immunol & Microbiol, Unit Avian Med, Ithaca, NY 14853 USA
机构:
Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Unit Avian Med, Ithaca, NY 14853 USACornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Unit Avian Med, Ithaca, NY 14853 USA
Calnek, BW
;
Harris, RW
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机构:Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Unit Avian Med, Ithaca, NY 14853 USA
Harris, RW
;
Buscaglia, C
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机构:Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Unit Avian Med, Ithaca, NY 14853 USA
Buscaglia, C
;
Schat, KA
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机构:Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Unit Avian Med, Ithaca, NY 14853 USA
Schat, KA
;
Lucio, B
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机构:Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Unit Avian Med, Ithaca, NY 14853 USA
机构:
CORNELL UNIV,NEW YORK STATE COLL VET MED,DEPT AVIAN & AQUAT ANIM MED,ITHACA,NY 14853CORNELL UNIV,NEW YORK STATE COLL VET MED,DEPT AVIAN & AQUAT ANIM MED,ITHACA,NY 14853
HELLER, ED
;
SCHAT, KA
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CORNELL UNIV,NEW YORK STATE COLL VET MED,DEPT AVIAN & AQUAT ANIM MED,ITHACA,NY 14853CORNELL UNIV,NEW YORK STATE COLL VET MED,DEPT AVIAN & AQUAT ANIM MED,ITHACA,NY 14853
机构:
Cornell Univ, Coll Vet Med, Dept Immunol & Microbiol, Unit Avian Med, Ithaca, NY 14853 USACornell Univ, Coll Vet Med, Dept Immunol & Microbiol, Unit Avian Med, Ithaca, NY 14853 USA
机构:
Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Unit Avian Med, Ithaca, NY 14853 USACornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Unit Avian Med, Ithaca, NY 14853 USA
Calnek, BW
;
Harris, RW
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h-index: 0
机构:Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Unit Avian Med, Ithaca, NY 14853 USA
Harris, RW
;
Buscaglia, C
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机构:Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Unit Avian Med, Ithaca, NY 14853 USA
Buscaglia, C
;
Schat, KA
论文数: 0引用数: 0
h-index: 0
机构:Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Unit Avian Med, Ithaca, NY 14853 USA
Schat, KA
;
Lucio, B
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h-index: 0
机构:Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Unit Avian Med, Ithaca, NY 14853 USA
机构:
CORNELL UNIV,NEW YORK STATE COLL VET MED,DEPT AVIAN & AQUAT ANIM MED,ITHACA,NY 14853CORNELL UNIV,NEW YORK STATE COLL VET MED,DEPT AVIAN & AQUAT ANIM MED,ITHACA,NY 14853
HELLER, ED
;
SCHAT, KA
论文数: 0引用数: 0
h-index: 0
机构:
CORNELL UNIV,NEW YORK STATE COLL VET MED,DEPT AVIAN & AQUAT ANIM MED,ITHACA,NY 14853CORNELL UNIV,NEW YORK STATE COLL VET MED,DEPT AVIAN & AQUAT ANIM MED,ITHACA,NY 14853