Early cell-mediated immune responses to Marek's disease virus in two chicken lines with defined major histocompatibility complex antigens

被引:39
作者
Garcia-Camacho, L
Schat, KA
Brooks, R
Bounous, D
机构
[1] Univ Georgia, Coll Vet Med, Dept Pathol, Athens, GA 30602 USA
[2] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Unit Avian Hlth, Ithaca, NY 14853 USA
关键词
cell-mediated immunity; cytotoxic lymphocytes; genetic resistance; glycoprotein B; innate immunity; MHC-restricted; cytotoxicity; Marek's disease; NK cells;
D O I
10.1016/S0165-2427(03)00140-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
N2a and P2a chickens, resistant and susceptible to Marek's disease (MD), respectively, were used to examine relationships between major histocompatibility complex (MHC)-restricted cytotoxic T lymphocytes (CTL) and natural killer (NK)-like cell activity with resistance to infection with Marek's disease virus (MDV). Ten-day-old chickens were infected with MDV and euthanatized at selected times to evaluate for NK cell and MHC-restricted cytotoxicity. The N2a MDV-infected chickens had an early cell-mediated immune response characterized by a sustained NK-like cytotoxicity that coincided with a measurable MHC-cytotoxicity that was lower than controls. Although MHC-restricted and NK cell cytotoxicity was demonstrated in P2a MDV-infected chickens at 8 dpi, both abruptly decreased and remained low for the remainder of the 20-day experiment. The critical time point that may determine the resistance to MD appears to be within the first 2 weeks post-infection. Improvement of the chicken NK cell activity may be a good candidate for both selection and immunomodulation MD control programs. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码:145 / 153
页数:9
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