HIV-inhibitory gallotannins from Lepidobotrys staudtii

被引：16

作者：

Bokesch, HR

McKee, TC

Currens, MJ

Gulakowski, RJ

McMahon, JB

Cardellina, JH

Boyd, MR

机构：

[1] NCI,DIV CANC TREATMENT DIAG & CTR,DEV THERAPEUT PROGRAM,LAB DRUG DISCOVERY RES & DEV,FREDERICK,MD 21702

[2] NCI,FREDERICK CANC RES & DEV CTR,SAIC,FREDERICK,MD 21702

来源：

NATURAL PRODUCT LETTERS | 1996年 / 8卷 / 02期

关键词：

Lepidobotrys staudtii; galloylquinic acid; HIV-2 inhibitory tannins;

D O I：

10.1080/10575639608043252

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three galloylquinic acids, 1,3,4,5-tetra-O-galloylquinic acid (1), 3,4,5-tri-O-galloylquinic acid (2), and methyl 3,4,5-tri-O-galloylquinate (3) were isolated from the stem bark of the monotypic plant Lepidobotrys staudtii. Compound 1 protected target cells from the cytopathic effects of HIV-1 and HIV-2 and also exhibited potent inhibition of cellular DNA polymerases, as well as of the reverse transcriptases of HIV-1 and HIV-2, but not of other retroviruses tested.

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页码：133 / 136

页数：4

相关论文

共 9 条

[1]

CHEN YC, 1979, J BIOL CHEM, V254, P1678

[2] HIV-1 REVERSE-TRANSCRIPTASE PURIFIED FROM A RECOMBINANT STRAIN OF ESCHERICHIA-COLI [J].

CLARK, PK ;

FERRIS, AL ;

MILLER, DA ;

HIZI, A ;

KIM, KW ;

DERINGERBOYER, SM ;

MELLINI, ML ;

CLARK, AD ;

ARNOLD, GF ;

LEBHERZ, WB ;

ARNOLD, E ;

MUSCHIK, GM ;

HUGHES, SH .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1990, 6 (06) :753-764

[3] A SEMIAUTOMATED MULTIPARAMETER APPROACH FOR ANTI-HIV DRUG SCREENING [J].

GULAKOWSKI, RJ ;

MCMAHON, JB ;

STALEY, PG ;

MORAN, RA ;

BOYD, MR .

JOURNAL OF VIROLOGICAL METHODS, 1991, 33 (1-2) :87-100

[4]

MCCORMICK JL, UNPUB J NAT PROD

[5] ANTI-AIDS AGENTS .1. ISOLATION AND CHARACTERIZATION OF 4 NEW TETRAGALLOYLQUINIC ACIDS AS A NEW CLASS OF HIV REVERSE-TRANSCRIPTASE INHIBITORS FROM TANNIC-ACID [J].

NISHIZAWA, M ;

YAMAGISHI, T ;

DUTSCHMAN, GE ;

PARKER, WB ;

BODNER, AJ ;

KILKUSKIE, RE ;

CHENG, YC ;

LEE, KH .

JOURNAL OF NATURAL PRODUCTS, 1989, 52 (04) :762-768

[6] CHARACTERIZATION OF A NOVEL INHIBITOR OF HUMAN DNA-POLYMERASES - 3,4,5-TRI-ORTHO-GALLOYLQUINIC ACID [J].

PARKER, WB ;

NISHIZAWA, M ;

FISHER, MH ;

YE, N ;

LEE, KH ;

CHENG, YC .

BIOCHEMICAL PHARMACOLOGY, 1989, 38 (21) :3759-3765

[7] 3'-AZIDO-3'-DEOXYTHYMIDINE TRIPHOSPHATE AS AN INHIBITOR AND SUBSTRATE OF PURIFIED HUMAN-IMMUNODEFICIENCY-VIRUS REVERSE-TRANSCRIPTASE [J].

STCLAIR, MH ;

RICHARDS, CA ;

SPECTOR, T ;

WEINHOLD, KJ ;

MILLER, WH ;

LANGLOIS, AJ ;

FURMAN, PA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (12) :1972-1977

[8] ULOSANTOIN, A POTENT INSECTICIDE FROM THE SPONGE ULOSA-RUETZLERI [J].

VANWAGENEN, BC ;

LARSEN, R ;

CARDELLINA, JH ;

RANDAZZO, D ;

LIDERT, ZC ;

SWITHENBANK, C .

JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (02) :335-337

[9] NEW SOLUBLE-FORMAZAN ASSAY FOR HIV-1 CYTOPATHIC EFFECTS - APPLICATION TO HIGH-FLUX SCREENING OF SYNTHETIC AND NATURAL-PRODUCTS FOR AIDS-ANTIVIRAL ACTIVITY [J].

WEISLOW, OS ;

KISER, R ;

FINE, DL ;

BADER, J ;

SHOEMAKER, RH ;

BOYD, MR .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (08) :577-586