A C-elegans CLIC-like protein required for intracellular tube formation and maintenance

被引：126

作者：

Berry, KL

Bülow, HE

Hall, DH

Hobert, O ^{[1
]}

机构：

[1] Columbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, Ctr Neurobiol & Behav, New York, NY 10032 USA

[2] Yeshiva Univ Albert Einstein Coll Med, Ctr C Elegans Anat, Dept Neurosci, Bronx, NY 10461 USA

来源：

SCIENCE | 2003年 / 302卷 / 5653期

关键词：

D O I：

10.1126/science.1087667

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Caenorhabditis elegans excretory canal is composed of a single elongated and branched cell that is tunneled by an inner lumen of apical character. Loss of the exc-4 gene causes a cystic enlargement of this intracellular tube. exc-4 encodes a member of the chloride intracellular channel (CLIC) family of proteins. EXC-4 protein localizes to various tubular membranes in distinct cell types, including the lumenal membrane of the excretory tubes. A conserved 55 - amino acid domain enables EXC-4 translocation from the cytosol to the lumenal membrane. The tubular architecture of this membrane requires EXC-4 for both its formation and maintenance.

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页码：2134 / 2137

页数：4

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