Adenomatous Polyposis Coli mutations in colon cancer - slipping off the brake and onto the gas pedal

被引:5
作者
Boquoi, A. [1 ]
Enders, G. H. [1 ]
机构
[1] Fox Chase Canc Ctr, Dept Med Sci, Philadelphia, PA 19111 USA
关键词
colon cancer; aneuploidy; tetraploidy; genomic instability; adenomatous polyposis coli; min mice; cytokinesis; mitotic spindle; cancer initiation;
D O I
10.4161/cbt.7.4.5917
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The adenomatous polyposis coli gene (APC) is frequently mutated in sporadic colon cancer and has been described as a "gatekeeper" for colon tumorigenesis. A recent paper published in the Journal of Cell Biology by Caldwell et al.. reports that clinically relevant mutations in APC induce defective cytokinesis and aneuploidy, independent of Wnt signaling. This insight adds to evidence that mutations in APC may play a causative role in tumor formation in part by mediating genomic instability.
引用
收藏
页码:485 / 487
页数:3
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