共 14 条
Adenomatous Polyposis Coli mutations in colon cancer - slipping off the brake and onto the gas pedal
被引:5
作者:

Boquoi, A.
论文数: 0 引用数: 0
h-index: 0
机构:
Fox Chase Canc Ctr, Dept Med Sci, Philadelphia, PA 19111 USA Fox Chase Canc Ctr, Dept Med Sci, Philadelphia, PA 19111 USA

Enders, G. H.
论文数: 0 引用数: 0
h-index: 0
机构:
Fox Chase Canc Ctr, Dept Med Sci, Philadelphia, PA 19111 USA Fox Chase Canc Ctr, Dept Med Sci, Philadelphia, PA 19111 USA
机构:
[1] Fox Chase Canc Ctr, Dept Med Sci, Philadelphia, PA 19111 USA
关键词:
colon cancer;
aneuploidy;
tetraploidy;
genomic instability;
adenomatous polyposis coli;
min mice;
cytokinesis;
mitotic spindle;
cancer initiation;
D O I:
10.4161/cbt.7.4.5917
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
The adenomatous polyposis coli gene (APC) is frequently mutated in sporadic colon cancer and has been described as a "gatekeeper" for colon tumorigenesis. A recent paper published in the Journal of Cell Biology by Caldwell et al.. reports that clinically relevant mutations in APC induce defective cytokinesis and aneuploidy, independent of Wnt signaling. This insight adds to evidence that mutations in APC may play a causative role in tumor formation in part by mediating genomic instability.
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页码:485 / 487
页数:3
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