Neighborhood politics: the immunoregulatory function of organ-resident liver endothelial cells

被引：125

作者：

Knolle, PA ^{[1
]}

Limmer, A ^{[1
]}

机构：

[1] Univ Heidelberg, ZMBH, D-59120 Heidelberg, Germany

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 08期

关键词：

D O I：

10.1016/S1471-4906(01)01957-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The liver is known for its ability to induce antigen (Ag)-specific immune tolerance. Among the different cell populations involved in the induction of hepatic tolerance, the liver sinusoidal endothelial cells (LSECs) are particularly important because they are highly efficient at presenting soluble Ags to CD4(+) and CD8(+) T cells. The crosspresentation of soluble Ags to CD8(+) T cells was believed previously to be restricted to professional Ag-presenting cells (APCs) such as dendritic cells (DCs). However, in contrast to DCs, crosspresentation by LSECs can induce Ag-specific immune tolerance. It is proposed that these organ-resident APCs act as sessile hepatic APCs that control the immune responses to soluble blood-borne Ags, in concert with APCs in lymphatic tissue.

引用

页码：432 / 437

页数：6

共 57 条

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