PARP Inhibitors in Cancer Therapy: Promise, Progress, and Puzzles

被引：51

作者：

Ellisen, Leif W. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02114 USA

来源：

CANCER CELL | 2011年 / 19卷 / 02期

关键词：

POLY(ADP-RIBOSE) POLYMERASE; TUMORS;

D O I：

10.1016/j.ccr.2011.01.047

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：165 / 167

页数：3

共 10 条

[1] Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase [J].

Bryant, HE ;

Schultz, N ;

Thomas, HD ;

Parker, KM ;

Flower, D ;

Lopez, E ;

Kyle, S ;

Meuth, M ;

Curtin, NJ ;

Helleday, T .

NATURE, 2005, 434 (7035) :913-917

[2] Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy [J].

Farmer, H ;

McCabe, N ;

Lord, CJ ;

Tutt, ANJ ;

Johnson, DA ;

Richardson, TB ;

Santarosa, M ;

Dillon, KJ ;

Hickson, I ;

Knights, C ;

Martin, NMB ;

Jackson, SP ;

Smith, GCM ;

Ashworth, A .

NATURE, 2005, 434 (7035) :917-921

[3] Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers. [J].

Fong, Peter C. ;

Boss, David S. ;

Yap, Timothy A. ;

Tutt, Andrew ;

Wu, Peijun ;

Mergui-Roelvink, Marja ;

Mortimer, Peter ;

Swaisland, Helen ;

Lau, Alan ;

O'Connor, Mark J. ;

Ashworth, Alan ;

Carmichael, James ;

Kaye, Stan B. ;

Schellens, Jan H. M. ;

de Bono, Johann S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (02) :123-134

[4] Triple-Negative Breast Cancer [J].

Foulkes, William D. ;

Smith, Ian E. ;

Reis-Filho, Jorge S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (20) :1938-1948

[5] Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics [J].

He, Jin-xue ;

Yang, Chun-hao ;

Miao, Ze-hong .

ACTA PHARMACOLOGICA SINICA, 2010, 31 (09) :1172-1180

[6] A phase II trial of the PARP inhibitor veliparib (ABT888) and temozolomide for metastatic breast cancer. [J].

Isakoff, S. J. ;

Overmoyer, B. ;

Tung, N. M. ;

Gelman, R. S. ;

Giranda, V. L. ;

Bernhard, K. M. ;

Habin, K. R. ;

Ellisen, L. W. ;

Winer, E. P. ;

Goss, P. E. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15)

[7] The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets [J].

Krishnakumar, Raga ;

Kraus, W. Lee .

MOLECULAR CELL, 2010, 39 (01) :8-24

[8] miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors [J].

Moskwa, Patryk ;

Buffa, Francesca M. ;

Pan, Yunfeng ;

Panchakshari, Rohit ;

Gottipati, Ponnari ;

Muschel, Ruth J. ;

Beech, John ;

Kulshrestha, Ritu ;

Abdelmohsen, Kotb ;

Weinstock, David M. ;

Gorospe, Myriam ;

Harris, Adrian L. ;

Helleday, Thomas ;

Chowdhury, Dipanjan .

MOLECULAR CELL, 2011, 41 (02) :210-220

[9] Iniparib plus Chemotherapy in Metastatic Triple-Negative Breast Cancer. [J].

O'Shaughnessy, Joyce ;

Osborne, Cynthia ;

Pippen, John E. ;

Yoffe, Mark ;

Patt, Debra ;

Rocha, Christine ;

Koo, Ingrid Chou ;

Sherman, Barry M. ;

Bradley, Charles .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (03) :205-214

[10] Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial [J].

Tutt, Andrew ;

Robson, Mark ;

Garber, Judy E. ;

Domchek, Susan M. ;

Audeh, M. William ;

Weitzel, Jeffrey N. ;

Friedlander, Michael ;

Arun, Banu ;

Loman, Niklas ;

Schmutzler, Rita K. ;

Wardley, Andrew ;

Mitchell, Gillian ;

Earl, Helena ;

Wickens, Mark ;

Carmichael, James .

LANCET, 2010, 376 (9737) :235-244

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