Alzheimer's disease genetics: lessons to improve disease modelling

被引：32

作者：

Guerreiro, Rita J. ^{[1
]}

Hardy, John ^{[1
]}

机构：

[1] UCL, Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2011年 / 39卷

基金：

英国惠康基金;

关键词：

Alzheimer's disease; amyloid beta-peptide; complement system; disease modelling; genome-wide association study (GWAS); lipid metabolism; GENOME-WIDE ASSOCIATION; AMYLOID PRECURSOR PROTEIN; HIGH-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-E; SUSCEPTIBILITY GENES; CEREBROSPINAL-FLUID; IDENTIFIES VARIANTS; QUANTITATIVE TRAIT; ANALYSIS REVEALS; COMMON VARIANTS;

D O I：

10.1042/BST0390910

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present review, we look back at the recent history of GWAS (genome-wide association studies) in AD (Alzheimer's disease) and integrate the major findings with current knowledge of biological processes and pathways. These topics are essential for the development of animal models, which will be fundamental to our complete understanding of AD.

引用

页码：910 / 916

页数：7

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